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Transferrin receptor 1 (RD) binds iron-loaded transferrin and allows its internalization in the cytoplasm. Human serum transferrin also forms complexes with metals other than iron, including uranium in the uranyl form (UO22+). Can the uranyl-saturated transferrin (TUr2) follow the receptor-mediated iron-acquisition pathway? In cell-free assays, TUr2 interacts with RD in two different steps. The first...
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