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TheS. cerevisiaea-factor, YIIKGVFWDPAC(s-farnesyl)-OCH 3 , is one of two peptide mating pheromones which mediate cell-cell communication inS. cerevisiae.We previously reported that replacing Gly 5 withd-Ala led to a 4–6 fold increase in activity while thel-Ala 5 homolog was 4 to 16-fold less active than the wildtype. To clarify the structural implications of these findings,...
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