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The human ether-a-go-go related gene (HERG) constitutes the pore forming subunit of I Kr , a K + current involved in repolarization of the cardiac action potential. While mutations in HERG predispose patients to cardiac arrhythmias (Long QT syndrome; LQTS), altered function of HERG regulators are undoubtedly LQTS risk factors. We have combined RNA interference with behavioral screening...
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