Search results for: Abhijit Chakrabarti

Items from 1 to 20 out of 62 results

article

Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins

Dipayan Bose, Shantanu Aggarwal, Debashree Das, Chandrabhas Narayana, more

Hemoglobin oxidation due to oxidative stress and disease conditions leads to the generation of ROS (reactive oxygen species) and membrane attachment of hemoglobin in‐vivo, where its redox activity leads to peroxidative damage of membrane lipids and proteins. Spectrin, the major component of the red blood cell (RBC) membrane skeleton, is known to interact with hemoglobin and, here this interaction...

article

Localizing the chaperone activity of erythroid spectrin

Dipayan Bose, Abhijit Chakrabarti

Cytoskeleton > 76 > 6 > 383 - 397

Spectrin, the major protein of the erythrocyte membrane skeleton has canonically been thought to only serve a structural function. We have previously described a novel chaperone‐like property of spectrin and also hypothesized that the chaperone activity and binding of a hydrophobic ligand, Prodan are localized in the self‐association domain. Here we probe the location and molecular origin of the chaperone...

article

Structure‐activity relationship of heme and its analogues in membrane damage and inhibition of fusion

Debashree Das, Pradip K. Tarafdar, Abhijit Chakrabarti

FEBS Letters > 592 > 14 > 2458 - 2465

Under pathological conditions, such as sickle cell disease and malaria, heme concentration increases considerably, and it induces membrane damage. As sickled and normal erythrocytes contain high cholesterol: phospholipid ratio, we investigated the role of lipid composition, chain length, and unsaturation on the partitioning and leakage of hemin in phospholipid vesicles. To establish structure‐activity...

article

Substrate specificity in the context of molecular chaperones

Dipayan Bose, Abhijit Chakrabarti

IUBMB Life > 69 > 9 > 647 - 659

Molecular chaperones are one of the key players in protein biology and as such their structure and mechanism of action have been extensively studied. However the substrate specificity of molecular chaperones has not been well investigated. This review aims to summarize what is known about the substrate specificity and substrate recognition motifs of chaperones so as to better understand what substrate...

article

Effect of pH on stability, conformation, and chaperone activity of erythroid & non-erythroid spectrin

Dipayan Bose, Malay Patra, Abhijit Chakrabarti

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics > 2017 > 1865 > 6 > 694-702

Spectrin, a major component of the eukaryotic membrane skeleton, has been shown to have chaperone like activity. Here we investigate the pH induced changes in the structure and stability of erythroid and brain spectrin by spectroscopic methods. We also correlate these changes with modulations of chaperone potential at different pH. We have followed the pH induced structural changes by circular dichroism...

article

Localization and dynamics of the anticarcinogenic curcumin with GM₁ and other miceller assemblies

Malay Patra, Manoj Mandal, Abhijit Chakrabarti, Chaitali Mukhopadhyay

Glycoconjugate Journal > 2017 > 34 > 2 > 171-179

Structural transitions involving shape changes play an important role in cellular physiology and enhance the bioavailability of the natural food like curcumin in surfactant aggregates. In this work, we have studied the localization, dynamics and stability of curcumin in various miceller assemblies using a combination of absorbance and fluorescence spectroscopic approaches. The measurements of absorption...

article

Erythrocyte and platelet proteomics in hematological disorders

Abhijit Chakrabarti, Suchismita Halder, Shilpita Karmakar

PROTEOMICS – Clinical Applications > 10 > 4 > 403 - 414

Erythrocytes undergo ineffective erythropoesis, hemolysis, and premature eryptosis in sickle cell disease and thalassemia. Abnormal hemoglobin variants associated with hemoglobinopathy lead to vesiculation, membrane instability, and loss of membrane asymmetry with exposal of phosphatidylserine. This potentiates thrombin generation resulting in activation of the coagulation cascade responsible for...

article

Platelet proteomics in thalassemia: Factors responsible for hypercoagulation

Shilpita Karmakar, Debasis Banerjee, Abhijit Chakrabarti

PROTEOMICS – Clinical Applications > 10 > 3 > 239 - 247

PurposeThalassemias can be defined as a group with inherited hemolytic anemia due to differential expressions of α and β globin genes. Hemoglobin E combined with β thalassemia (HbEβ) creates high oxidative stress in platelets producing different degrees of pathophysiological severity. Numerous cases of thalassemia have been reported with thromboembolic complications due to the hypercoagulable state,...

chapter

A Fluorescence Quenching Method to Study Interactions of Hemoglobin Derivatives with Erythroid Spectrin

Abhijit Chakrabarti

Reviews in Fluorescence 2004 > Reviews in Fluorescence 2007 > 363-377

We have used a simple fluorescence technique to study the interactions of erythroid spectrin with hemoglobin and the globin chains. This could be used to study interactions of other proteins with hemoglobin derivatives and other heme proteins. The concentration-dependent change in the fluorescence intensity of fluorescein-conjugated spectrin (F-spectrin) in the presence of oxy-hemoglobin and other...

chapter

OPF governed determination of location and size of distribution generators using gravitational search algorithm

Barnali Kundu Sarkar, Abhijit Chakrabarti

2016 2nd International Conference on Control, Instrumentation, Energy & Communication (CIEC) > 446 - 450

2016 2nd International Conference on Control, Instrumentation, Energy & Communication (CIEC)

In the electricity pricing, the congestion management has become extremely important and it can impose unavoidable problems in electricity trading. In this paper, Gravitational Search Algorithm (GSA) based optimization is performed to address the optimal power flow (OPF) problem governed by contribution factor based ranking and nodal congestion price based ranking in order to achieve congestion relief...

chapter

Analysis of Vulnerability indices of power grid integrated DG units based on Complex Network theory

Tamalika Chowdhury, Abhijit Chakrabarti, Chandan Kumar Chanda

2015 Annual IEEE India Conference (INDICON) > 1 - 5

2015 Annual IEEE India Conference (INDICON)

The application of Complex Networks have significantly advanced in the last decade and brought about valuable insights to properties of real world systems by evaluating their structure, topology and construction. Similarly here an electric power network is considered as a complex network where its buses are the nodes and edges are the links of a complex network graph respectively. Power grid Vulnerability...

article

Hemoglobin interacting proteins and implications of spectrin hemoglobin interaction

Avik Basu, Abhijit Chakrabarti

Journal of Proteomics > 2015 > 128 > C > 469-475

In this report we have analyzed interacting partners of hemoglobin inside erythrocyte and sought possible implications of hemoglobin–spectrin interaction. Our list of identified cytosolic hemoglobin interacting proteins includes redox regulators like peroxiredoxin-2, Cu–Zn superoxide dismutase, catalase, aldehyde dehydrogenase-1, flavin reductase and chaperones like HSP70, α-hemoglobin stabilizing...

article

Proteome analysis of the triton-insoluble erythrocyte membrane skeleton

Avik Basu, Sandra Harper, Esther N. Pesciotta, Kaye D. Speicher, more

Journal of Proteomics > 2015 > 128 > C > 298-305

Erythrocyte shape and membrane integrity is imparted by the membrane skeleton, which can be isolated as a Triton X-100 insoluble structure that retains the biconcave shape of intact erythrocytes, indicating isolation of essentially intact membrane skeletons. These erythrocyte “Triton Skeletons” have been studied morphologically and biochemically, but unbiased proteome analysis of this substructure...

article

Differential regulation of urine proteins in urothelial neoplasm

Suchismita Halder, Ranjan Kumar Dey, Anadi Roy Chowdhury, Palash Bhattacharyya, more

Journal of Proteomics > 2015 > 127 > Part A > 185-192

Urothelial neoplasm of the urinary bladder has a high rate of multifocality and recurrence. To understand this we first need to understand the changes in the molecular level that distinguishes a normal individual from a patient and also a low grade neoplasm from a high grade. In this work we aim to study the urine proteome of Indian patients with urothelial neoplasm categorised on the basis of their...

article

Peanut protein sensitivity towards trace iron: A novel mode to ebb allergic response

Sumanta Kumar Ghatak, Dipanwita Majumdar, Achintya Singha, Souvik Sen, more

Food Chemistry > 2015 > 176 > Complete > 308-313

Peanut is a rich source of plant protein which is inexpensive and abundant in nature. The peanut proteins however cause hypersensitive immunogenic responses in certain individuals. A minute amount of contamination may cause strong allergic reactions and even death. Many chemical pretreatment procedures have been developed and prescribed earlier for removal of this allergenicity. In the present article...

article

Differential interactions of two local anesthetics with phospholipid membrane and nonerythroid spectrin: Localization in presence of cholesterol and ganglioside, GM1

Abhijit Chakrabarti, Malay Patra, A. Chakrabarti, M. Patra

BBA - Biomembranes > 2015 > 1848 > 3 > 821-832

Interactions of two local anesthetics, dibucaine and tetracaine have been studied with phospholipid vesicles containing cholesterol and/or monosialogangliosides (GM ₁ ) using fluorescence spectroscopy. The fluorescence intensity of tetracaine showed a marked increase with the increasing molar ratio of the phospholipid to tetracaine, while that of dibucaine showed opposite effects. Steady state...

article

Differential proteomics study of platelets in asymptomatic constitutional macrothrombocytopenia: altered levels of cytoskeletal proteins

Shilpita Karmakar, Sutapa Saha, Debasis Banerjee, Abhijit Chakrabarti

European Journal of Haematology > 94 > 1 > 43 - 50

ObjectivesHarris platelet syndrome (HPS), also known as asymptomatic constitutional macrothrombocytopenia (ACMT), is an autosomal dominant platelet disorder characterized by mild‐to‐severe thrombocytopenia and giant platelets with normal platelet aggregation and absence of bleeding symptoms. We have attempted a comparative proteomics study for profiling of platelet proteins in healthy vs. pathological...

article

Organization and Dynamics of Tryptophan Residues in Brain Spectrin: Novel Insight into Conformational Flexibility

Madhurima Mitra, Arunima Chaudhuri, Malay Patra, Chaitali Mukhopadhyay, more

Journal of Fluorescence > 2015 > 25 > 3 > 707-717

Brain spectrin enjoys overall structural and sequence similarity with erythroid spectrin, but less is known about its function. We utilized the fluorescence properties of tryptophan residues to monitor their organization and dynamics in brain spectrin. Keeping in mind the functional relevance of hydrophobic binding sites in brain spectrin, we monitored the organization and dynamics of brain spectrin...

article

Fluorescence study of the effect of cholesterol on spectrin–aminophospholipid interactions

Madhurima Mitra, Malay Patra, Abhijit Chakrabarti

European Biophysics Journal > 2015 > 44 > 8 > 635-645

The ability of the membrane skeletal protein spectrin to interact with phospholipids, and aminophospholipids in particular, in both natural and model membranes, is well documented. The present study involves phospholipid-induced quenching of tryptophan fluorescence to probe spectrin–membrane interactions in the presence and absence of cholesterol. We performed the experiments on small unilamellar...

article

Binding of hemin, hematoporphyrin, and protoporphyrin with erythroid spectrin: fluorescence and molecular docking studies

Debashree Das, Malay Patra, Abhijit Chakrabarti

European Biophysics Journal > 2015 > 44 > 3 > 171-182

Free heme has toxic effects, for example lipid peroxidation, DNA damage, and protein aggregation. In severe hemolysis, which occurs during pathological states, for example sickle cell disease, ischemia reperfusion, and malaria, levels of free heme increase inside erythrocytes. The purpose of this study was to investigate whether spectrin, the major erythroid cytoskeleton protein, is involved...

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INFONA - science communication portal

Search results for: Abhijit Chakrabarti

Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins

Localizing the chaperone activity of erythroid spectrin

Structure‐activity relationship of heme and its analogues in membrane damage and inhibition of fusion

Substrate specificity in the context of molecular chaperones

Effect of pH on stability, conformation, and chaperone activity of erythroid & non-erythroid spectrin

Localization and dynamics of the anticarcinogenic curcumin with GM₁ and other miceller assemblies

Erythrocyte and platelet proteomics in hematological disorders

Platelet proteomics in thalassemia: Factors responsible for hypercoagulation

A Fluorescence Quenching Method to Study Interactions of Hemoglobin Derivatives with Erythroid Spectrin

OPF governed determination of location and size of distribution generators using gravitational search algorithm

Analysis of Vulnerability indices of power grid integrated DG units based on Complex Network theory

Hemoglobin interacting proteins and implications of spectrin hemoglobin interaction

Proteome analysis of the triton-insoluble erythrocyte membrane skeleton

Differential regulation of urine proteins in urothelial neoplasm

Peanut protein sensitivity towards trace iron: A novel mode to ebb allergic response

Differential interactions of two local anesthetics with phospholipid membrane and nonerythroid spectrin: Localization in presence of cholesterol and ganglioside, GM1

Differential proteomics study of platelets in asymptomatic constitutional macrothrombocytopenia: altered levels of cytoskeletal proteins

Organization and Dynamics of Tryptophan Residues in Brain Spectrin: Novel Insight into Conformational Flexibility

Fluorescence study of the effect of cholesterol on spectrin–aminophospholipid interactions

Binding of hemin, hematoporphyrin, and protoporphyrin with erythroid spectrin: fluorescence and molecular docking studies

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