Search results for: Mickaël Michaud

Items from 1 to 12 out of 12 results

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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

Yuting Ma, Sandy Adjemian, Stephen R. Mattarollo, Takahiro Yamazaki, more

Immunity > 2013 > 38 > 4 > 729-741

The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to T cells, however, remains a conundrum. We found that intratumoral CD11c ⁺ CD11b ⁺ Ly6C ^hi cells, which displayed some characteristics of inflammatory dendritic cells and included granulomonocytic...

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Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken André Olaussen, more

Cell Reports > 2012 > 2 > 5 > 1472

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Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer

Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken André Olaussen, more

Cell Reports > 2012 > 2 > 2 > 257-269

Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated...

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Molecular determinants of immunogenic cell death elicited by anticancer chemotherapy

Oliver Kepp, Lorenzo Galluzzi, Isabelle Martins, Frederic Schlemmer, more

Cancer and Metastasis Reviews > 2011 > 30 > 1 > 61-69

The success of some chemo- and radiotherapeutic regimens relies on the induction of immunogenic tumor cell death and on the induction of an anticancer immune response. Cells succumbing to immunogenic cell death undergo specific changes in their surface characteristics and release pro-immunogenic factors according to a defined spatiotemporal pattern. This stimulates antigen presenting cells such as...

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Surface‐exposed calreticulin in the interaction between dying cells and phagocytes

Isabelle Martins, Oliver Kepp, Lorenzo Galluzzi, Laura Senovilla, more

Annals of the New York Academy of Sciences > 1209 > 1 > 77 - 82

Phagocytosis is essential for pathogen elimination and for the removal of apoptotic corpses, a process that has been long considered immunologically silent. The phagocytic uptake of apoptotic/necrotic cells involves a plethora of molecules, including immunoglobulins, lectins, components of the complement system (all of which act as opsonins), as well as the phospholipid phosphatidylserine (PS) and...

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Mitochondrial gateways to cancer

Lorenzo Galluzzi, Eugenia Morselli, Oliver Kepp, Ilio Vitale, more

Molecular Aspects of Medicine > 2010 > 31 > 1 > 1-20

Mitochondria are required for cellular survival, yet can also orchestrate cell death. The peculiar biochemical properties of these organelles, which are intimately linked to their compartmentalized ultrastructure, provide an optimal microenvironment for multiple biosynthetic and bioenergetic pathways. Most intracellular ATP is generated by mitochondrial respiration, which also represents the most...

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Immunogenic cell death modalities and their impact on cancer treatment

Oliver Kepp, Antoine Tesniere, Frederic Schlemmer, Mickael Michaud, more

Apoptosis > 2009 > 14 > 4 > 364-375

It is still enigmatic under which circumstances cellular demise induces an immune response or rather remains immunologically silent. Moreover, the question remains open under which circumstances apoptotic, autophagic or necrotic cells are immunogenic or tolerogenic. Although apoptosis appears to be morphologically homogenous, recent evidence suggests that the pre-apoptotic surface-exposure of calreticulin...

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Gene Therapy of the Typical Multidrug Resistance Phenotype of Cancers: A New Hope?

Stëphane Labialle, Guila Dayan, Mickaél Michaud, Stëphane Barakat, more

Seminars in Oncology > 2005 > 32 > 6 > 583-590

The multidrug resistance (MDR) phenotype of cancers has generated a large amount of research, owing to its constant fatal clinical outcome. Many studies have focused on the discovery of chemomodulators; however, in spite of this huge effort, the side effects that these products induce, and their additive toxicity when used in the presence of anticancer drugs, have led to the disaffection of the pharmaceutical...

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Major cytogenetic aberrations and typical multidrug resistance phenotype of uveal melanoma: Current views and new therapeutic prospects

Loris G. Baggetto, Joël Gambrelle, Guila Dayan, Stéphane Labialle, more

Cancer Treatment Reviews > 2005 > 31 > 5 > 361-379

Uveal melanoma is the most frequent intra-ocular cancer. The recent development of new chromosome-related technologies have permitted the elucidation of both the cytogenetics and the natural history of this disease. Fifty to 60% of uveal melanomas are linked to a monosomy 3, which appears as an early and determinant event in tumor progression. Tumors with this anomaly have a very poor prognosis. Recent...