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Ethanol is oxidized in the brain to acetaldehyde, which can condense with dopamine to generate (R/S)‐salsolinol [(RS)‐SAL]. Racemic salsolinol [(RS)‐SAL] is self‐infused by rats into the posterior ventral tegmental area (VTA) at significantly lower concentrations than those of acetaldehyde, suggesting that (RS)‐SAL is a most active product of ethanol metabolism. Early studies showed that repeated...
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