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MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that are made up of 18–25 nucleotides that function in post-transcriptional gene regulation. The expression of miRNAs is highly conserved and essential in regulating many cellular processes including formation, maintenance and the remodelling of the extracellular matrix (ECM). In this review, we examine different ECM molecules and the...
The proteoglycan aggrecan is a major component of cartilage, and degradation of aggrecan is associated with aging and a number of pathological conditions. To investigate the effects of the accumulation of G1 domain from degraded aggrecan, we overexpressed the G1 domain in cell culture. Exogenous addition of the expressed G1 gene product to chondrocyte cultures retarded the attachment of chondrocytes...
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