Search results for: Nicholas Fisher

Items from 1 to 20 out of 24 results

article

The cytochrome bc₁ complex as an antipathogenic target

Nicholas Fisher, Brigitte Meunier, Giancarlo A. Biagini

The cytochrome bc₁ complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc₁ is an enzyme that contains two (ubi)quinone/quinol‐binding sites, which can be exploited for the development of fungicidal and...

article

Mitochondrial complex III Q_i‐site inhibitor resistance mutations found in laboratory selected mutants and field isolates

Pierre Mounkoro, Thomas Michel, Rafik Benhachemi, Georgiana Surpateanu, more

Pest Management Science > 75 > 8 > 2107 - 2114

BACKGROUND Complex III inhibitors targeting the Q_i‐site have been known for decades; some are used or being developed as antimicrobial compounds. Target site resistance mutations have been reported in laboratory‐selected mutants and in field isolates. Here, we present a brief overview of mutations found in laboratory‐selected resistant mutants. We also provide a study of mutations observed in field...

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The antimalarial compound ELQ‐400 is an unusual inhibitor of the bc₁ complex, targeting both Q_o and Q_i sites

Zehua Song, Bogdan I. Iorga, Pierre Mounkoro, Nicholas Fisher, more

FEBS Letters > 592 > 8 > 1346 - 1356

Inhibitors of the mitochondrial respiratory chain cytochrome bc₁ complex, such as the antimalarial atovaquone and ELQ‐300, and many well‐studied compounds, are classified as either Q_o or Q_i site inhibitors based on their site of action. Here, we investigated the site of action of ELQ‐400 that showed an unusual behaviour, being effective against parasites resistant to the Q_o site inhibitor atovaquone...

article

Poor Actual Availability of Publicly Accessible Automated External Defibrillators Limit Their Value in the Treatment of Out-of-Hospital Cardiac Arrest

Thalib Mowjood, Daniel Garofalo, Kris Gagliardi, Nicholas Fisher, more

Heart, Lung and Circulation > 2017 > 26 > S1 > S9

article

Redox regulation of the antimycin A sensitive pathway of cyclic electron flow around photosystem I in higher plant thylakoids

Deserah D. Strand, Nicholas Fisher, Geoffry A. Davis, David M. Kramer

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2016 > 1857 > 1 > 1-6

The chloroplast must regulate supply of reducing equivalents and ATP to meet rapid changes in downstream metabolic demands. Cyclic electron flow around photosystem I (CEF) is proposed to balance the ATP/NADPH budget by using reducing equivalents to drive plastoquinone reduction, leading to the generation of proton motive force and subsequent ATP synthesis. While high rates of CEF have been observed...

article

Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex — Analysis of Plasmodium-like mutations in the yeast enzyme

Zehua Song, Jérôme Clain, Bogdan I. Iorga, Cindy Vallières, more

BBA - Bioenergetics > 2015 > 1847 > 12 > 1487-1494

The respiratory chain bc₁ complex is central to mitochondrial bioenergetics and the target of antiprotozoals. We characterized a modified yeast bc₁ complex that more closely resemble Plasmodium falciparum enzyme. The mutant version was generated by replacing ten cytochrome b Q_o site residues by P. falciparum equivalents. The Plasmodium-like changes caused a major dysfunction of the catalytic mechanism...

article

Non-photochemical reduction of thylakoid photosynthetic redox carriers in vitro: Relevance to cyclic electron flow around photosystem I?

Nicholas Fisher, David M. Kramer

Biochimica et Biophysica Acta (BBA) - Bioenergetics > 2014 > 1837 > 12 > 1944-1954

Non-photochemical (dark) increases in chlorophyll a fluorescence yield associated with non-photochemical reduction of redox carriers (F_npr) have been attributed to the reduction of plastoquinone (PQ) related to cyclic electron flow (CEF) around photosystem I. In vivo, this rise in fluorescence is associated with activity of the chloroplast plastoquinone reductase (plastid NAD(P)H:plastoquinone oxidoreductase)...

article

Inhibiting Plasmodium cytochrome bc1: a complex issue

Victoria Barton, Nicholas Fisher, Giancarlo A Biagini, Stephen A Ward, more

Current Opinion in Chemical Biology > 2010 > 14 > 4 > 440-446

The cytochrome bc ₁ complex is a key mitochondrial enzyme that catalyses transfer of electrons maintaining the membrane potential of mitochondria. Currently, atovaquone is the only drug in clinical use targeting the Plasmodium falciparum bc ₁ complex. The rapid emergence of resistance to atovaquone resulted in a costly combination with proguanil (Malarone™), limiting its widespread...

article

Gene identification and functional characterisation of Plasmodium falciparum succinate dehydrogenase

Thomas Antoine, Nicholas Fisher, Giancarlo Biagini, Stephen Ward

BBA - Bioenergetics > 2010 > 1797 > Supplement > 71

article

A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum

Nicholas Fisher, Alasdair Hill, Alison Mbekeani, Alison Shone, more

BBA - Bioenergetics > 2010 > 1797 > Supplement > 80

article

The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem

Ashley J. Warman, Teresa Rito, Nicholas Fisher, Neil G. Berry, more

BBA - Bioenergetics > 2010 > 1797 > Supplement > 117-118

article

Transforming Rhinacanthin Analogues from Potent Anticancer Agents into Potent Antimalarial Agents

Ngampong Kongkathip, Narathip Pradidphol, Komkrit Hasitapan, Ronald Grigg, more

Journal of Medicinal Chemistry > 2010 > 53 > 3 > 1211 - 1221

article

Effects of phase on homeostatic spike rates

Nicholas Fisher, Sachin S. Talathi, Paul R. Carney, William L. Ditto

Biological Cybernetics > 2010 > 102 > 5 > 427-440

Recent experimental results by Talathi et al. (Neurosci Lett 455:145–149, 2009) showed a divergence in the spike rates of two types of population spike events, representing the putative activity of the excitatory and inhibitory neurons in the CA1 area of an animal model for temporal lobe epilepsy. The divergence in the spike rate was accompanied by a shift in the phase of oscillations between these...

article

S15.15 Remodelling bc1 complex Qo site in yeast to study acquired resistance to inhibitors

Brigitte Meunier, Nicholas Fisher

BBA - Bioenergetics > 2008 > 1777 > Supplement > S105-S106

article

S4.24 Modelling, cloning and expression of the P. falciparum NADH dehydrogenase

Nicholas Fisher, Stephen A. Ward, Giancarlo A. Biagini

BBA - Bioenergetics > 2008 > 1777 > Supplement > S38

article

Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary

Nicholas Fisher, Patrick G. Bray, Stephen A. Ward, Giancarlo A. Biagini

Trends in Parasitology > 2008 > 24 > 1 > 9-10

article

Methylmercury in Marine Ecosystems: Spatial Patterns and Processes of Production, Bioaccumulation, and Biomagnification

Celia Chen, Aria Amirbahman, Nicholas Fisher, Gareth Harding, more

EcoHealth > 2008 > 5 > 4 > 399-408

The spatial variation of MeHg production, bioaccumulation, and biomagnification in marine food webs is poorly characterized but critical to understanding the links between sources and higher trophic levels, such as fish that are ultimately vectors of human and wildlife exposure. This article discusses both large and local scale processes controlling Hg supply, methylation, bioaccumulation, and transfer...

article

Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)

Amanda F. Cashen, Ajit K. Shah, Laura Todt, Nicholas Fisher, more

Cancer Chemotherapy and Pharmacology > 2008 > 61 > 5 > 759-766

Purpose In this study, pharmacokinetics (PK) of decitabine administered as a 3-h intravenous infusion of 15 mg/m² every 8 h for 3 days (cycles repeated every 6 weeks) was evaluated in patients with MDS or AML. Methods The PK of this dosing regimen was evaluated in sixteen patients with MDS or AML. Plasma samples were obtained pre-dose and during the first 8-h dosing interval on each dosing day during...

article

The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

Nicholas Fisher, Patrick G. Bray, Stephen A. Ward, Giancarlo A. Biagini

Trends in Parasitology > 2007 > 23 > 7 > 305-310

The operation of a type II NADH:quinone oxidoreductase (PfNDH2), also known as alternative Complex I, in the mitochondrion of the human malaria parasite, Plasmodium falciparum, has recently been described. Unlike the Complex I of typical mitochondria, type II NADH:quinone oxidoreductases do not have transmembrane domains and are not involved directly in proton (H ⁺ ) pumping. Here, we present...

article

ATR-FTIR Redox Difference Spectroscopy of Yarrowia lipolytica and Bovine Complex I ^†

Douglas Marshall, Nicholas Fisher, Ljuban Grigic, Volker Zickermann, more

Biochemistry > 2006 > 45 > 17 > 5458 - 5467

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INFONA - science communication portal

Search results for: Nicholas Fisher

The cytochrome bc₁ complex as an antipathogenic target

Mitochondrial complex III Q_i‐site inhibitor resistance mutations found in laboratory selected mutants and field isolates

The antimalarial compound ELQ‐400 is an unusual inhibitor of the bc₁ complex, targeting both Q_o and Q_i sites

Poor Actual Availability of Publicly Accessible Automated External Defibrillators Limit Their Value in the Treatment of Out-of-Hospital Cardiac Arrest

Redox regulation of the antimycin A sensitive pathway of cyclic electron flow around photosystem I in higher plant thylakoids

Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex — Analysis of Plasmodium-like mutations in the yeast enzyme

Non-photochemical reduction of thylakoid photosynthetic redox carriers in vitro: Relevance to cyclic electron flow around photosystem I?

Inhibiting Plasmodium cytochrome bc1: a complex issue

Gene identification and functional characterisation of Plasmodium falciparum succinate dehydrogenase

A novel drug for uncomplicated malaria: Targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNDH2) of Plasmodium falciparum

The type II NADH: Quinone oxidoreductase of Mycobacterium tuberculosis: A novel drug target for an age-old problem

Transforming Rhinacanthin Analogues from Potent Anticancer Agents into Potent Antimalarial Agents

Effects of phase on homeostatic spike rates

S15.15 Remodelling bc1 complex Qo site in yeast to study acquired resistance to inhibitors

S4.24 Modelling, cloning and expression of the P. falciparum NADH dehydrogenase

Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary

Methylmercury in Marine Ecosystems: Spatial Patterns and Processes of Production, Bioaccumulation, and Biomagnification

Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)

The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle

ATR-FTIR Redox Difference Spectroscopy of Yarrowia lipolytica and Bovine Complex I ^†

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