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The structure and dynamics of theR 6 human insulin hexamer are investigated by two- and three-dimensional homonuclear 1 H-NMR spectroscopy. TheR 6 hexamer, stabilized by Zn 2+ and phenol, provides a model of an allosteric protein assembly and is proposed to mimic aspects of receptor recognition. Despite the large size of the assembly (36 kDa), its extreme thermal...
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