Search results for: Aimin Huang

Items from 1 to 20 out of 43 results

article

Targeted inhibition of ACK1 can inhibit the proliferation of hepatocellular carcinoma cells through the PTEN/AKT/mTOR pathway

Bin Wang, Kai Song, Lihong Chen, Hongying Su, more

Cell Biochemistry and Function > 38 > 5 > 642 - 650

Activated Cdc42‐associated kinase 1 (ACK1) expression is upregulated in hepatocellular carcinoma (HCC) tissues and other tumour tissues. However, the function and regulatory mechanism of ACK1 in HCC remains unclear. In this study, the expression of pTyr284‐ACK1, pSer473‐AKT and PTEN in HCC was detected by immunohistochemistry, and its clinicopathological significance was analysed. Then, ACK1‐targeted...

article

Effect of lignin esters on improving the thermal properties of poly(vinyl chloride)

Xiaohong Zhao, Yanjuan Zhang, Huayu Hu, Zuqiang Huang, more

Journal of Applied Polymer Science > 136 > 11 > n/a - n/a

To improve the thermal stability of poly(vinyl chloride) (PVC) and the utilization of lignin (L), different L esters were added to PVC to produce the plates with enhanced thermal stabilities. The properties and structures of the L ester–PVC plates and the properties of the L esters and their mixtures with PVC were analyzed by universal mechanical testing, static thermal stability testing, thermogravimetry–Fourier...

article

Mathematical Analysis of the Jin-Neelin Model of El Niño-Southern-Oscillation

Yining Cao, Mickaël D. Chekroun, Aimin Huang, Roger Temam

Chinese Annals of Mathematics, Series B > 2019 > 40 > 1 > 1-38

The Jin-Neelin model for the El Niño–Southern Oscillation (ENSO for short) is considered for which the authors establish existence and uniqueness of global solutions in time over an unbounded channel domain. The result is proved for initial data and forcing that are sufficiently small. The smallness conditions involve in particular key physical parameters of the model such as those that control the...

article

Effects of interaction with gene carrier polyethyleneimines on conformation and enzymatic activity of pig heart lactate dehydrogenase

Fan Wang, Junyong Mo, Aimin Huang, Min Zhang, more

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2018 > 204 > C > 217-224

Polyethyleneimine (PEI) has long been considered as “golden standard” for polymeric gene delivery carrier, however also induces cytotoxicity. To make a further insight into the molecular basis of PEI cytotoxicity, fluorescence, absorption and circular dichroism spectroscopy were conducted to investigate the influence of PEI (average molecular weight 25,000 and 1800 Da) on the conformation of pig heart...

article

Conformational change of lysozyme on the interaction with gene carrier polyethyleneimine

Fan Wang, Xu Wang, Min Zhang, Aimin Huang, more

International Journal of Biological Macromolecules > 2018 > 117 > C > 532-537

Polyethyleneimine (PEI) has been considered as “golden standard” for polymeric gene delivery carriers, however also induces cytotoxicity. To reveal the molecular basis of PEI cytotoxicity, absorption, resonance Rayleigh scattering, fluorescence, circular dichroism and isothermal titration calorimetry were conducted to investigate the interaction between PEI (average molecular weight 25,000 Da) and...

article

Tribological properties of nano cellulose fatty acid esters as ecofriendly and effective lubricant additives

Yanjuan Zhang, Liping Wei, Huayu Hu, Zengyan Zhao, more

Cellulose > 2018 > 25 > 5 > 3091-3103

Three cellulose esters, cellulose acetate-butyrate, cellulose acetate-octanoate, and cellulose acetate-laurate, were synthesized by both conventional co-reactant reaction (CCR) and mechanical activation-assisted co-reactant reaction (MACR) methods, and the corresponding nano-cellulose esters were prepared by high pressure homogenization to comparatively investigate their tribological properties as...

article

Reactivity of main components and substituent distribution in esterified sugarcane bagasse prepared by effective solid phase reaction

Tao Gan, Yanjuan Zhang, Yane Chen, Huayu Hu, more

Carbohydrate Polymers > 2018 > 181 > C > 633-641

Three main components of lignocellulose (cellulose, hemicellulose, and lignin isolated from sugarcane bagasse (SCB)) as well as holocellulose and SCB were modified with maleic acid by mechanical activation (MA)-assisted solid phase reaction (MASPR) technology. The order of reactivity was found to be lignin>hemicellulose>cellulose. The amorphous structure of lignin and hemicellulose mainly attributed...

article

Conformation and activity alteration of horseradish peroxidase induced by the interaction with gene carrier polyethyleneimines

Aimin Huang, Bangzhi Wei, Junyong Mo, Yajing Wang, more

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2018 > 188 > C > 90-98

Polyethyleneimine (PEI) has long been considered as “golden standard” for polymeric gene delivery carriers. However the molecular basis of the cytotoxicity of PEI is poorly understood. Little is known about the effects of PEI on the structure and functions of biomacromolecules. In this work, fluorescence, UV–vis absorption, circular dichroism spectroscopy were conducted to investigate the influence...

article

Correlation of lysosome-associated protein transmembrane-4β gene overexpression with the malignant phenotypes of hepatocellular carcinoma

Hongying Su, Tao Xu, Xiongfei Huang, Shengbing Zang, more

Pathology - Research and Practice > 2017 > 213 > 12 > 1536-1541

Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies, for which hepatitis B virus (HBV) chronic infection constitutes a major risk factor. The lysosome-associated protein transmembrane-4 β gene (LAPTM4B) is a recently identified gene that was found to be overexpressed in several types of cancer. However, the role of LAPTM4B in HCC tumorigenesis and progression has...

article

Esterification of bagasse cellulose with metal salts as efficient catalyst in mechanical activation-assisted solid phase reaction system

Tao Gan, Yanjuan Zhang, Yang Su, Huayu Hu, more

Cellulose > 2017 > 24 > 12 > 5371-5387

The present study focused on investigating the catalytic mechanism of metal salts (sodium hypophosphite, sodium bisulfate and ammonium ferric sulfate) for esterification of bagasse cellulose carried out by mechanical activation-assisted solid phase reaction in a stirring ball mill. FTIR analysis of the products confirmed that these metal salts could catalyze the esterification of cellulose. XRD, SEM,...

article

Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling

Jie Lin, Wansong Lin, Yunbin Ye, Liping Wang, more

Journal of Experimental & Clinical Cancer Research > 2017 > 36 > 1 > 1-14

Background Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. Methods Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pairs of human HCC and adjacent liver tissue samples. The role of Kindlin-2 in the...

article

PGE2 synthesis and signaling in malignant transformation and progression of human hepatocellular carcinoma

Shengbing Zang, Xiaojie Ma, Yanbin Wu, Wenwen Liu, more

Human Pathology > 2017 > 63 > C > 120-127

Prostaglandin E 2 (PGE₂), which is the most abundant prostaglandin produced in hepatocellular carcinoma (HCC), may be involved in hepatocarcinogenesis. Here, the amount of PGE₂ was significantly increased in HCC tissue and adjacent noncancerous tissues relative to normal liver tissue (P<.001). In addition, the expression of EP2 receptor was considerably upregulated in HCC tissue compared with the...

article

A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic framework

Xiaolong Zhang, Yongyi Zeng, Aixian Zheng, Zhixiong Cai, more

Microchimica Acta > 2017 > 184 > 7 > 1933-1940

The authors describe a fluorescence immunoassay for galectin-4, a candidate biomarker for various cancers. Glucose oxidase was encapsulated into a zeolitic imidazolate framework to give a composite (GOx/ZIF-8 composite) that acts as a signal-transduction tag via a biomimetic mineralization process. After modification of the composite with streptavidin, it binds biotinylated antibody against galectin-4...

article

Effects of gene carrier polyethyleneimines on the structure and binding capability of bovine serum albumin

Zhiyong Guo, Zhijie Kong, Yanshan Wei, Hua Li, more

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy > 2017 > 173 > C > 783-791

Polyethyleneimine (PEI), one of the most effective non-viral gene carriers, is also cytotoxic, however the molecular basis is poorly understood. Little is known about the effects of PEI on the structure and functions of the biomacromolecules. In this work, fluorescence, UV–vis absorption, circular dichroism (CD) spectroscopy and zeta-potential measurement were conducted to reveal the interaction between...

article

Effect of mechanical activation on structure changes and reactivity in further chemical modification of lignin

Xiaohong Zhao, Yanjuan Zhang, Huayu Hu, Zuqiang Huang, more

International Journal of Biological Macromolecules > 2016 > 91 > C > 1081-1089

Lignin was treated by mechanical activation (MA) in a customized stirring ball mill, and the structure and reactivity in further esterification were studied. The chemical structure and morphology of MA-treated lignin and the esterified products were analyzed by chemical analysis combined with UV/vis spectrometer, FTIR,NMR, SEM and particle size analyzer. The results showed that MA contributed to the...

article

Efficient solid‐phase synthesis of acetylated lignin and a comparison of the properties of different modified lignins

Xiaohong Zhao, Zuqiang Huang, Yanjuan Zhang, Mei Yang, more

Journal of Applied Polymer Science > 134 > 1 > n/a - n/a

The chemical modification of lignin can greatly enhance its functionality and exploit its application areas. To avoid the difficulties of separation and environmental pollution in the traditional liquid‐phase method, we prepared acetylated lignin by a mechanical‐activation‐assisted solid‐phase synthesis (MASPS) technology with a customized stirring ball mill as a reactor and studied its structure...

article

Magnetite nanocluster@poly(dopamine)-PEG@ indocyanine green nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo

Ming Wu, Qingtang Wang, Da Zhang, Naishun Liao, more

Colloids and Surfaces B: Biointerfaces > 2016 > 141 > C > 467-475

Multifunctional nanomaterials with the magnetic resonance imaging (MRI) guided tumor photothermal ablation ability have been extensively applied in biomedical research as one of the most exciting and challenging strategies for cancer treatment. Nevertheless, most of these nanomaterials still suffer from low accumulation in tumor tissues and insufficient photothermal ablation of tumors so far. Here,...

article

Structure and functional properties of octenyl succinic anhydride modified starch prepared by a non‐conventional technology

Huayu Hu, Wandong Liu, Jian Shi, Zuqiang Huang, more

Starch ‐ Stärke > 68 > 1-2 > 151 - 159

This study investigated the direct production of octenyl succinic anhydride modified starch (OSA‐starch) by a non‐conventional mechanical activation (MA)‐assisted solid phase synthesis (MASPS) technology without the use of solvents and additives in a stirring ball mill. FTIR analysis confirmed that the OSA‐starches with different degrees of substitution (DS) had been successfully produced by MASPS...

article

Horseradish peroxidase and aptamer dual-functionalized nanoprobe for the amplification detection of alpha-methylacyl-CoA racemase

Yongyi Zeng, Aixian Zheng, Jing Wu, Zhixiong Cai, more

Analytica Chimica Acta > 2015 > 899 > Complete > 100-105

Alpha-methylacyl-CoA racemase (AMACR) is over-expressed in many cancer types and can serve as a novel diagnostic biomarker. Development of convenient and sensitive detection methods of AMACR is of particular importance for cancer diagnosis. Aptamers are a type of recognition elements, which possess many advantages over antibody, making them suitable for applications in biosensing and biotechnology...

article

Structural effects of organobentonites on controlled release of pretilachlor

Junyong Mo, Lintao Dai, Libiao Chen, Yajing Wang, more

Applied Clay Science > 2015 > 115 > Complete > 150-156

To provide controlled release properties to the formulation containing pretilachlor, organobentonites with different loading levels of dodecyltrimethyl ammonium chloride (DTMA) and hexadecyltrimethyl ammonium chloride (HTMA) were prepared and used as carrier. The organobentonites were characterized by Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) analysis, and the adsorption...

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INFONA - science communication portal

Search results for: Aimin Huang

Targeted inhibition of ACK1 can inhibit the proliferation of hepatocellular carcinoma cells through the PTEN/AKT/mTOR pathway

Effect of lignin esters on improving the thermal properties of poly(vinyl chloride)

Mathematical Analysis of the Jin-Neelin Model of El Niño-Southern-Oscillation

Effects of interaction with gene carrier polyethyleneimines on conformation and enzymatic activity of pig heart lactate dehydrogenase

Conformational change of lysozyme on the interaction with gene carrier polyethyleneimine

Tribological properties of nano cellulose fatty acid esters as ecofriendly and effective lubricant additives

Reactivity of main components and substituent distribution in esterified sugarcane bagasse prepared by effective solid phase reaction

Conformation and activity alteration of horseradish peroxidase induced by the interaction with gene carrier polyethyleneimines

Correlation of lysosome-associated protein transmembrane-4β gene overexpression with the malignant phenotypes of hepatocellular carcinoma

Esterification of bagasse cellulose with metal salts as efficient catalyst in mechanical activation-assisted solid phase reaction system

Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling

PGE2 synthesis and signaling in malignant transformation and progression of human hepatocellular carcinoma

A fluorescence based immunoassay for galectin-4 using gold nanoclusters and a composite consisting of glucose oxidase and a metal-organic framework

Effects of gene carrier polyethyleneimines on the structure and binding capability of bovine serum albumin

Effect of mechanical activation on structure changes and reactivity in further chemical modification of lignin

Efficient solid‐phase synthesis of acetylated lignin and a comparison of the properties of different modified lignins

Magnetite nanocluster@poly(dopamine)-PEG@ indocyanine green nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo

Structure and functional properties of octenyl succinic anhydride modified starch prepared by a non‐conventional technology

Horseradish peroxidase and aptamer dual-functionalized nanoprobe for the amplification detection of alpha-methylacyl-CoA racemase

Structural effects of organobentonites on controlled release of pretilachlor

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