Search results for: Shaoqin Gong

Items from 1 to 20 out of 74 results

article

Overcoming the Blood–Brain Barrier for Gene Therapy via Systemic Administration of GSH‐Responsive Silica Nanocapsules

Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, more

CRISPR genome editing can potentially treat the root causes of many genetic diseases, including central nervous system (CNS) disorders. However, the promise of brain‐targeted therapeutic genome editing relies on the efficient delivery of biologics bypassing the blood–brain barrier (BBB), which represents a major challenge in the development of CRISPR therapeutics. We created and screened a library...

article

pH‐Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA

Ruosen Xie, Xiuxiu Wang, Yuyuan Wang, Mingzhou Ye, more

Advanced Materials > 34 > 23 > n/a - n/a

Clustered regularly interspaced short palindromic repeat (CRISPR)‐associated protein 9 (Cas9) may offer new therapeutics for genetic diseases through gene disruption via nonhomologous end joining (NHEJ) or gene correction via homology‐directed repair (HDR). However, clinical translation of CRISPR technology is limited by the lack of safe and efficient delivery systems. Here, facilely fabricated pH‐responsive...

article

A Dual‐Responsive Antibiotic‐Loaded Nanoparticle Specifically Binds Pathogens and Overcomes Antimicrobial‐Resistant Infections

Mingzhou Ye, Yi Zhao, Yuyuan Wang, Miao Zhao, more

Advanced Materials > 33 > 9 > n/a - n/a

Antimicrobial resistant (AMR) infections are a growing threat to public health and there is a general lack of development in new antibiotics. Here, a dextran‐coated stimuli‐responsive nanoparticle (NP) that encapsulates the hydrophobic antibiotic, rifampicin, and specifically binds bacteria to overcome AMR infections is reported. The NP shows a strong affinity with a variety of pathogens in vitro...

article

Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications

Haotian Sun, William Erdman, Yuan Yuan, Mohamed Alaa Mohamed, more

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 12 > 6 > n/a - n/a

Crosslinked polymer nanocapsules (CPNCs) are hollowed nanoparticles with network‐like polymeric shells stabilized by primary bonds. CPNCs have drawn broad and significant interests as nanocarriers for biomedical applications in recent years. As compared with conventional polymeric nanoparticles systems without cavity and/or crosslinking architectures, CPNCs possess significant biomedical relevant...

article

pH‐Responsive Polymer–Drug Conjugate: An Effective Strategy to Combat the Antimicrobial Resistance

Mingzhou Ye, Yi Zhao, Yuyuan Wang, Nisakorn Yodsanit, more

Advanced Functional Materials > 30 > 39 > n/a - n/a

An urgent need for developing new antimicrobial approaches has emerged due to the imminent threat of antimicrobial‐resistant (AMR) pathogens. Bacterial infection can induce a unique microenvironment with low pH, which can be employed to trigger drug release and activation. Here, a pH‐responsive polymer–drug conjugate (PDC) capable of combating severe infectious diseases and overcoming AMR is reported...

article

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

Ravi B. Patel, Mingzhou Ye, Peter M. Carlson, Abigail Jaquish, more

Advanced Materials > 31 > 43 > n/a - n/a

Neoantigens induced by random mutations and specific to an individual's cancer are the most important tumor antigens recognized by T cells. Among immunologically “cold” tumors, limited recognition of tumor neoantigens results in the absence of a de novo antitumor immune response. These “cold” tumors present a clinical challenge as they are poorly responsive to most immunotherapies, including immune...

article

3D Microstructured Scaffolds to Support Photoreceptor Polarization and Maturation

Yei Hwan Jung, M. Joseph Phillips, Juhwan Lee, Ruosen Xie, more

Advanced Materials > 30 > 39 > n/a - n/a

Blinding disorders of the outer retina involve dysfunction and degeneration of photoreceptors. One potential approach to treat these forms of blindness is to repopulate the outer retina via a simple bolus injection of donor photoreceptors. However, this may not be ideal due to the highly polarized organization of photoreceptors that include apical light sensing photopigments and basal axon terminals...

article

A paradigm of endothelium-protective and stent-free anti-restenotic therapy using biomimetic nanoclusters

Bowen Wang, Guojun Chen, Go Urabe, Ruosen Xie, more

Biomaterials > 2018 > 178 > C > 293-301

Drug-eluting stents are the most commonly employed method to control post-angioplasty restenosis. Unfortunately, they exacerbate life-threatening stent thrombosis because of endothelium damage caused by both drug and stenting. To solve this major medical problem, an endothelium-protective and stent-free anti-restenotic method is highly desirable. Here we have generated a biomimetic intravenous delivery...

article

A review on core–shell structured unimolecular nanoparticles for biomedical applications

Guojun Chen, Yuyuan Wang, Ruosen Xie, Shaoqin Gong

Advanced Drug Delivery Reviews > 2018 > 130 > C > 58-72

Polymeric unimolecular nanoparticles (NPs) exhibiting a core-shell structure and formed by a single multi-arm molecule containing only covalent bonds have attracted increasing attention for numerous biomedical applications. This unique single-molecular architecture provides the unimolecular NP with superior stability both in vitro and in vivo, a high drug loading capacity, as well as versatile surface...

article

Highly Porous Polymer Aerogel Film‐Based Triboelectric Nanogenerators

Qifeng Zheng, Liming Fang, Haiquan Guo, Kefang Yang, more

Advanced Functional Materials > 28 > 13 > n/a - n/a

A novel class of high performance polymer porous aerogel film‐based triboelectric nanogenerators (A‐NGs) is demonstrated. The A‐NGs, made of a pair of highly porous polymer films, exhibit much higher triboelectric outputs than the corresponding dense polymer film‐based triboelectric nanogenerators (D‐NGs) under the same mechanical stress. The triboelectric outputs of the A‐NGs increase significantly...

article

Fabrication of polycaprolactone electrospun fibers with different hierarchical structures mimicking collagen fibrils for tissue engineering scaffolds

Lin Jiang, Liwei Wang, Nathan Wang, Shaoqin Gong, more

Applied Surface Science > 2018 > 427 > PA > 311-325

The ability to topographically mimic the surface features of collagen fibrils is an important step in the preparation of tissue engineering scaffolds. It is important to know which kinds of surface topographies of electrospun fibers are more favorable for cell growth. In this study, fibers with three kinds of hierarchical-structured surfaces were fabricated by electrospinning to mimic collagen fibrils...

article

Tumor-targeted pH/redox dual-sensitive unimolecular nanoparticles for efficient siRNA delivery

Guojun Chen, Yuyuan Wang, Ruosen Xie, Shaoqin Gong

Journal of Controlled Release > 2017 > 259 > C > 105-114

A unique pH/redox dual-sensitive cationic unimolecular nanoparticle (NP) enabling excellent endosomal/lysosomal escape and efficient siRNA decomplexation inside the target cells was developed for tumor-targeted delivery of siRNA. siRNA was complexed into the cationic core of the unimolecular NP through electrostatic interactions. The cationic core used for complexing siRNA contained reducible disulfide...

article

A new class of flexible nanogenerators consisting of porous aerogel films driven by mechanoradicals

Yanfeng Tang, Qifeng Zheng, Bo Chen, Zhenqiang Ma, more

Nano Energy > 2017 > 38 > C > 401-411

Flexible nanogenerators (NGs) that are capable of harvesting ubiquitous mechanical energy from ambient environments have attracted significant attention during the past decade. Herein, a simple and scalable technique has been demonstrated to fabricate a new class of high-performance flexible compact triboelectric NGs using porous aerogel films. These porous aerogel film-based NGs can exhibit significant...

article

Carboplatin‐Complexed and cRGD‐Conjugated Unimolecular Nanoparticles for Targeted Ovarian Cancer Therapy

Yuyuan Wang, Liwei Wang, Guojun Chen, Shaoqin Gong

Macromolecular Bioscience > 17 > 5 > n/a - n/a

Platinum‐based chemotherapy has been widely used to treat cancers including ovarian cancer; however, it suffers from dose‐limiting toxicity. Judiciously designed drug nanocarriers can enhance the anticancer efficacy of platinum‐based chemotherapy while reducing its systemic toxicity. Herein the authors report a stable and water‐soluble unimolecular nanoparticle constructed from a hydrophilic multi‐arm...

article

Neuroendocrine Tumor‐Targeted Upconversion Nanoparticle‐Based Micelles for Simultaneous NIR‐Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging

Guojun Chen, Renata Jaskula‐Sztul, Corinne R. Esquibel, Irene Lou, more

Advanced Functional Materials > 27 > 8 > n/a - n/a

Although neuroendocrine tumors (NETs) are slow growing, they are frequently metastatic at the time of discovery and no longer amenable to curative surgery, emphasizing the need for the development of other treatments. In this study, multifunctional upconversion nanoparticle (UCNP)‐based theranostic micelles are developed for NET‐targeted and near‐infrared (NIR)‐controlled combination chemotherapy...

article

An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration

Lei Zhao, Guojun Chen, Jun Li, Yingmei Fu, more

Journal of Controlled Release > 2017 > 247 > C > 153-166

Glaucoma is a common blinding disease characterized by loss of retinal ganglion cells (RGCs). To date, there is no clinically available treatment directly targeting RGCs. We aim to develop an RGC-targeted intraocular drug delivery system using unimolecular micelle nanoparticles (unimNPs) to prevent RGC loss. The unimNPs were formed by single/individual multi-arm star amphiphilic block copolymer poly(amidoamine)–polyvalerolactone–poly(ethylene...

article

Triaxial compressive strain in bilayer graphene enabled by nitride stressor layer

Solomon Mikael, Jung-Hun Seo, Dong-Wook Park, Munho Kim, more

Extreme Mechanics Letters > 2017 > 11 > Complete > 77-83

A technique that can be used to viably create triaxially strained bilayer graphene on any desirable location by simple patterning was developed. Unlike the conventional graphene strain engineering methods, the photolithographically defined spoke patterns and compressive strained Si₃N₄ layer deposited by plasma-enhanced chemical vapor deposition (PECVD) system enable the creation of locally confined...

article

Orthogonal model and experimental data for analyzing wood-fiber-based tri-axial ribbed structural panels in bending

Jinghao Li, John F. Hunt, Shaoqin Gong, Zhiyong Cai

Holz als Roh- und Werkstoff > 2017 > 75 > 1 > 5-15

This paper presents an analysis of 3-dimensional engineered structural panels (3DESP) made from wood-fiber-based laminated paper composites. Since the existing models for calculating the mechanical behavior of core configurations within sandwich panels are very complex, a new simplified orthogonal model (SOM) using an equivalent element has been developed. This model considers both linear and nonlinear...

article

Synthesis of polyvinyl alcohol/cellulose nanofibril hybrid aerogel microspheres and their use as oil/solvent superabsorbents

Tianliang Zhai, Qifeng Zheng, Zhiyong Cai, Hesheng Xia, more

Carbohydrate Polymers > 2016 > 148 > C > 300-308

Superhydrophobic and crosslinked poly(vinyl alcohol) (PVA)/cellulose nanofibril (CNF) aerogel microspheres were prepared via a combination of the water-in-oil (W/O) emulsification process with the freeze-drying process, followed by thermal chemical vapor deposition of methyltrichlorosilane. The oil phase and the cooling agent were judiciously selected to ensure that the frozen ice microspheres can...

article

Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer

Ashley M. Brinkman, Guojun Chen, Yidan Wang, Curtis J. Hedman, more

Biomaterials > 2016 > 101 > C > 20-31

Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer for which there is no available targeted therapy. TNBC cases contribute disproportionately to breast cancer-related mortality, thus the need for novel and effective therapeutic methods is urgent. We have previously shown that a National Cancer Institute (NCI) investigational drug aminoflavone (AF) exhibits strong growth...

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INFONA - science communication portal

Search results for: Shaoqin Gong

Overcoming the Blood–Brain Barrier for Gene Therapy via Systemic Administration of GSH‐Responsive Silica Nanocapsules

pH‐Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA

A Dual‐Responsive Antibiotic‐Loaded Nanoparticle Specifically Binds Pathogens and Overcomes Antimicrobial‐Resistant Infections

Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications

pH‐Responsive Polymer–Drug Conjugate: An Effective Strategy to Combat the Antimicrobial Resistance

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

3D Microstructured Scaffolds to Support Photoreceptor Polarization and Maturation

A paradigm of endothelium-protective and stent-free anti-restenotic therapy using biomimetic nanoclusters

A review on core–shell structured unimolecular nanoparticles for biomedical applications

Highly Porous Polymer Aerogel Film‐Based Triboelectric Nanogenerators

Fabrication of polycaprolactone electrospun fibers with different hierarchical structures mimicking collagen fibrils for tissue engineering scaffolds

Tumor-targeted pH/redox dual-sensitive unimolecular nanoparticles for efficient siRNA delivery

A new class of flexible nanogenerators consisting of porous aerogel films driven by mechanoradicals

Carboplatin‐Complexed and cRGD‐Conjugated Unimolecular Nanoparticles for Targeted Ovarian Cancer Therapy

Neuroendocrine Tumor‐Targeted Upconversion Nanoparticle‐Based Micelles for Simultaneous NIR‐Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging

An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration

Triaxial compressive strain in bilayer graphene enabled by nitride stressor layer

Orthogonal model and experimental data for analyzing wood-fiber-based tri-axial ribbed structural panels in bending

Synthesis of polyvinyl alcohol/cellulose nanofibril hybrid aerogel microspheres and their use as oil/solvent superabsorbents

Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer

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