Search results for: Jennifer L. Peters

Items from 1 to 14 out of 14 results

article

Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

Michelle L. Churchman, Maoxiang Qian, Geertruy te Kronnie, Ranran Zhang, more

Cancer Cell > 2018 > 33 > 5 > 937-948.e8

Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causing aberrant cell-cell and cell-stroma interaction, and decreased sensitivity to tyrosine...

article

CNS angiogenesis and barriergenesis occur simultaneously

Robyn A. Umans, Hannah E. Henson, Fangzhou Mu, Chaithanyarani Parupalli, more

Developmental Biology > 2017 > 425 > 2 > 101-108

The blood-brain barrier (BBB) plays a vital role in the central nervous system (CNS). A comprehensive understanding of BBB development has been hampered by difficulties in observing the differentiation of brain endothelial cells (BECs) in real-time. Here, we generated two transgenic zebrafish line, Tg(glut1b:mCherry) and Tg(plvap:EGFP), to serve as in vivo reporters of BBB development. We showed that...

article

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

Si Ming Man, Rajendra Karki, Miwa Sasai, David E. Place, more

Cell > 2016 > 167 > 2 > 382-396.e17

The inflammasome is an intracellular signaling complex, which on recognition of pathogens and physiological aberration, drives activation of caspase-1, pyroptosis, and the release of the pro-inflammatory cytokines IL-1β and IL-18. Bacterial ligands must secure entry into the cytoplasm to activate inflammasomes; however, the mechanisms by which concealed ligands are liberated in the cytoplasm have...

article

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia

Michelle L. Churchman, Jonathan Low, Chunxu Qu, Elisabeth M. Paietta, more

Cancer Cell > 2015 > 28 > 3 > 343-356

Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here, we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations synergistically promote the development of an aggressive lymphoid leukemia. Ikzf1 alterations result...

article

Effects of immunization with natural and recombinant lysine decarboxylase on canine gingivitis development

Jennifer L. Peters, Paul L. DeMars, Lindsay M. Collins, Julie A. Stoner, more

Vaccine > 2012 > 30 > 47 > 6706-6712

Periodontal disease, gingival inflammation (gingivitis) and periodontal attachment loss (periodontitis), causes tooth loss and susceptibility to chronic inflammation. Professionally scaling and cleaning the teeth regularly controls the disease, but is expensive in companion animals. Eikenella corrodens is common in canine oral cavities where it is a source of lysine decarboxylase (LDC). In human dental...

article

The Glucoamylase Inhibitor Acarbose Is a Direct Activator of Phosphorylase Kinase

Owen W. Nadeau, Weiya Liu, Igor G. Boulatnikov, Jessica M. Sage, more

Biochemistry > 2010 > 49 > 31 > 6505 - 6507

article

Expressed Phosphorylase b Kinase and Its αγδ Subcomplex as Regulatory Models for the Rabbit Skeletal Muscle Holoenzyme

Igor G. Boulatnikov, Jennifer L. Peters, Owen W. Nadeau, Jessica M. Sage, more

Biochemistry > 2009 > 48 > 42 > 10183 - 10191

article

Time’s arrow flies like a bird: Two paradoxes for avian circadian biology

Vincent M. Cassone, Jiffin K. Paulose, Melissa G. Whitfield-Rucker, Jennifer L. Peters

General and Comparative Endocrinology > 2009 > 163 > 1-2 > 109-116

Biological timekeeping in birds is a fundamental feature of avian physiology, behavior and ecology. The physiological basis for avian circadian rhythmicity has pointed to a multi-oscillator system of mutually coupled pacemakers in the pineal gland, eyes and hypothalamic suprachiasmatic nuclei (SCN). In passerines, the role of the pineal gland and its hormone melatonin is particularly important. More...

article

The Role of Ganglioside GM ₁ in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers

Seungpyo Hong, Rahul Rattan, István J. Majoros, Douglas G. Mullen, more

Bioconjugate Chemistry > 2009 > 20 > 8 > 1503 - 1513

article

HER2 Specific Tumor Targeting with Dendrimer Conjugated Anti-HER2 mAb

Rameshwer Shukla, Thommey P. Thomas, Jennifer L. Peters, Ankur M. Desai, more

Bioconjugate Chemistry > 2006 > 17 > 5 > 1109 - 1115

article

Interaction of Polycationic Polymers with Supported Lipid Bilayers and Cells: Nanoscale Hole Formation and Enhanced Membrane Permeability

Seungpyo Hong, Pascale R. Leroueil, Elizabeth K. Janus, Jennifer L. Peters, more

Bioconjugate Chemistry > 2006 > 17 > 3 > 728 - 734

article

Melatonin modulates intercellular communication among cultured chick astrocytes

Jennifer L. Peters, Vincent M. Cassone, Mark J. Zoran

Brain Research > 2005 > 1031 > 1 > 10-19

Melatonin, a pineal neurohormone, mediates circadian and seasonal processes in birds and mammals. Diencephalic astrocytes are sites of action, at least in birds, since they express melatonin receptors and melatonin affects their metabolism. We tested whether astrocytic calcium waves are also modulated by melatonin. Calcium waves, which we found to be regulated in cultured chick glial cells by an IP...

article

Ultrastructure at carbon fiber microelectrode implantation sites after acute voltammetric measurements in the striatum of anesthetized rats

Jennifer L. Peters, LeeAnn H. Miner, Adrian C. Michael, Susan R. Sesack

Journal of Neuroscience Methods > 2004 > 137 > 1 > 9-23

This work seeks to establish the feasibility of characterizing the ultrastructure of brain tissue disruption associated with the implantation of carbon fiber voltammetric microelectrodes. In vivo recording was performed by fast scan cyclic voltammetry in conjunction with carbon fiber microelectrodes (3.5μm radius) in the striatum of rats anesthetized with chloral hydrate. After 4h of in vivo recording,...

article

Carbon fiber microelectrodes with multiple sensing elements for in vivo voltammetry

Shawn F Dressman, Jennifer L Peters, Adrian C Michael

Journal of Neuroscience Methods > 2002 > 119 > 1 > 75-81

Electrically evoked dopamine release was monitored in the striatum of anesthetized rats using voltammetric microelectrode assemblies with two to four separately addressable carbon fiber sensing elements. The sensing elements were disk-shaped, had a diameter of about 1 μm, and were separated from each other by less than 15 μm. The microelectrodes were used to monitor extracellular dopamine at multiple...

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