Search results for: Jens Pietzsch

Items from 1 to 20 out of 81 results

article

Shell engineering in soft alginate‐based capsules for culturing liver spheroids

Xuan Peng, Željko Janićijević, Sandy Lemm, Markus Laube, more

Biotechnology Journal > 18 > 6 > n/a - n/a

Functional interaction between cancer cells and the surrounding microenvironment is still not sufficiently understood, which motivates the tremendous interest for the development of numerous in vitro tumor models. Diverse parameters, for example, transport of nutrients and metabolites, availability of space in the confinement, etc. make an impact on the size, shape, and metabolism of the tumoroids...

article

A Self‐Assembled Matrix System for Cell‐Bioengineering Applications in Different Dimensions, Scales, and Geometries

Yong Xu, Michelle Patino Gaillez, Kai Zheng, Dagmar Voigt, more

Small > 18 > 13 > n/a - n/a

Stem cell bioengineering and therapy require different model systems and materials in different stages of development. If a chemically defined biomatrix system can fulfill most tasks, it can minimize the discrepancy among various setups. By screening biomaterials synthesized through a coacervation‐mediated self‐assembling mechanism, a biomatrix system optimal for 2D human mesenchymal stromal cell...

article

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas

Paal W Wallace, Catleen Conrad, Sascha Brückmann, Ying Pang, more

The Journal of Pathology > 251 > 4 > 378 - 387

Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours with a hereditary background in over one‐third of patients. Mutations in succinate dehydrogenase (SDH) genes increase the risk for PPGLs and several other tumours. Mutations in subunit B (SDHB) in particular are a risk factor for metastatic disease, further highlighting the importance of identifying SDHx mutations for patient...

article

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas

Paal W. Wallace, Catleen Conrad, Sascha Brückmann, Ying Pang, more

The Journal of Pathology > n/a - n/a

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours with a hereditary background in over one third of patients. Mutations in succinate dehydrogenase (SDH) genes increase the risk for PPGLs and several other tumours. Mutations in subunit B (SDHB) in particular are a risk factor for metastatic disease, further highlighting the importance of identifying SDH mutations for patient...

article

Active Tumor Targeting: Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging (Small 7/2020)

Kritee Pant, Christin Neuber, Kristof Zarschler, Johanna Wodtke, more

Small > 16 > 7 > n/a - n/a

Nanosniffers to track down cancer: in article number 1905013, Kristof Zarschler, Holger Stephan, and co‐workers design and synthesize functionalized bimodal probes for diagnostic cancer imaging. These renally excretible, actively targeted nanomaterials specifically detect their molecular target and show superior tumor accumulation in vivo.

article

Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging

Kritee Pant, Christin Neuber, Kristof Zarschler, Johanna Wodtke, more

Small > 16 > 7 > n/a - n/a

Active tumor targeting involves the decoration of nanomaterials (NMs) with oncotropic vector biomolecules that selectively recognize certain antigens on malignant cells or in the tumor microenvironment. This strategy can facilitate intracellular uptake of NM through specific interactions such as receptor‐mediated endocytosis and can lead to prolonged retention in the malignant tissues by preventing...

article

Radiochemical and radiopharmacological characterization of a ⁶⁴Cu‐labeled α‐MSH analog conjugated with different chelators

Feng Gao, Wiebke Sihver, Ralf Bergmann, Martin Walther, more

Journal of Labelled Compounds and Radiopharmaceuticals > 62 > 8 > 495 - 509

Radiolabeled α‐melanocyte‐stimulating hormone (α‐MSH) derivatives have a high potential for diagnosis and treatment of melanoma, because of high specificity and binding affinity to the melanocortin‐1 receptor (MC1R). Hence, the α‐MSH‐derived peptide NAP‐NS1 with a β‐Ala linker (ε‐Ahx‐β‐Ala‐Nle‐Asp‐His‐D‐Phe‐Arg‐Trp‐Gly‐NH₂) was conjugated to different chelators: either to NOTA (p‐SCN‐Bn‐1,4,7‐triazacyclononane‐1,4,7‐triacetic...

article

Synthesis and preliminary radiopharmacological characterisation of an ¹¹C‐labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins

Markus Laube, Maxim Frizler, Robert Wodtke, Christin Neuber, more

Journal of Labelled Compounds and Radiopharmaceuticals > 62 > 8 > 448 - 459

An O‐methyltyrosine‐containing azadipeptide nitrile was synthesised and investigated for its inhibitory activity towards cathepsins L, S, K, and B. Labelling with carbon‐11 was accomplished by reaction of the corresponding phenolic precursor with [¹¹C]methyl iodide starting from cyclotron‐produced [¹¹C]methane. Radiopharmacological evaluation of the resulting radiotracer in a mouse xenograft model...

article

Instant kit preparation of ⁶⁸Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [⁶⁸Ga]Ga-DATA-TOC

Jean-Philippe Sinnes, Johannes Nagel, Bradley P. Waldron, Theodosia Maina, more

EJNMMI Research > 2019 > 9 > 1 > 1-11

Purpose The widespread use of ⁶⁸Ga for positron emission tomography (PET) relies on the development of radiopharmaceutical precursors that can be radiolabelled and dispensed in a simple, quick, and convenient manner. The DATA (6-amino-1,4-diazapine-triacetate) scaffold represents a novel hybrid chelator architecture possessing both cyclic and acyclic character that may allow for facile access to ⁶⁸...

article

Synthesis, ¹⁸F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide

Reik Löser, Miriam Bader, Manuela Kuchar, Robert Wodtke, more

Amino Acids > 2019 > 51 > 2 > 219-244

The cell surface receptor claudin-4 (Cld-4) is upregulated in various tumours and represents an important emerging target for both diagnosis and treatment of solid tumours of epithelial origin. The C-terminal fragment of the Clostridium perfringens enterotoxin cCPE_290–319 appears as a suitable ligand for targeting Cld-4. The synthesis of this 30mer peptide was attempted via several approaches, which...

article

Exploring pitfalls of ⁶⁴Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer

Franziska Striese, Wiebke Sihver, Feng Gao, Ralf Bergmann, more

Amino Acids > 2018 > 50 > 10 > 1415-1431

The epidermal growth factor receptor (EGFR) represents an important molecular target for both radiotracer-based diagnostic imaging and radionuclide therapy of various cancer entities. For the delivery of radionuclides to the tumor, peptides hold great potential as a transport vehicle. With respect to EGFR, the peptide YHWYGYTPQNVI (GE11) has been reported to bind the receptor with high specificity...

article

An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment

Doreen Huebner, Christiane Rieger, Ralf Bergmann, Martin Ullrich, more

BMC Cancer > 2017 > 17 > 1 > 1-12

Background Novel theranostic options for high-risk non-muscle invasive bladder cancer are urgently needed. This requires a thorough evaluation of experimental approaches in animal models best possibly reflecting human disease before entering clinical studies. Although several bladder cancer xenograft models were used in the literature, the establishment of an orthotopic bladder cancer model in mice...

article

Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor

Jens Wiemer, Jörg Steinbach, Jens Pietzsch, Constantin Mamat

Journal of Labelled Compounds and Radiopharmaceuticals > 60 > 10 > 489 - 498

The visualization of Eph receptors, which are overexpressed in various tumor entities, using selective small molecule Eph inhibitors by means of positron emission tomography is a promising approach for tumor imaging. N‐(Pyrimidinyl)indazolamines represent a class of compounds, which are known to have high affinity especially for the EphB4 receptor. Radiofluorination of these compounds could provide...

article

Biological characterization of novel nitroimidazole‐peptide conjugates in vitro and in vivo

Ralf Bergmann, Katrin Splith, Jens Pietzsch, Michael Bachmann, more

Journal of Peptide Science > 23 > 7-8 > 597 - 609

Recently, we reported on the design of a multimodal peptide conjugate useful as delivery platform for targeting hypoxic cells. A nitroimidazole (2‐(2‐nitroimidazol‐1‐yl)acetic acid, NIA) moiety, which is selectively entrapped in hypoxic cells, was coupled to a cell‐penetrating peptide serving as the transporter. Furthermore, attachment of a bifunctional linker allowed the introduction of a diagnostic...

article

In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide–Oligosaccharide Interaction in Immunocompetent Nude Mice

Christoph Tondera, Robert Wieduwild, Elisabeth Röder, Carsten Werner, more

Advanced Functional Materials > 27 > 15 > n/a - n/a

Hydrogels can serve as matrices to mimic natural tissue function and be used for wide‐ranging applications such as tissue regeneration and drug delivery. Injectable hydrogels are particularly favorable because their uses are minimally invasive. However, creating moldable substance for injection often results in compromised function and stability. This study reports an injectable hydrogel system crosslinked...

article

Human Endothelial Cell Models in Biomaterial Research

Sandra Hauser, Friedrich Jung, Jens Pietzsch

Trends in Biotechnology > 2017 > 35 > 3 > 265-277

Endothelial cell (EC) models have evolved as important tools in biomaterial research due to ubiquitously occurring interactions between implanted materials and the endothelium. However, screening the available literature has revealed a gap between material scientists and physiologists in terms of their understanding of these biomaterial–endothelium interactions and their relative importance. Consequently,...

article

The why and how of amino acid analytics in cancer diagnostics and therapy

Friederike Manig, Konstantin Kuhne, Cläre von Neubeck, Uwe Schwarzenbolz, more

Journal of Biotechnology > 2017 > 242 > C > 30-54

Pathological alterations in cell functions are frequently accompanied by metabolic reprogramming including modifications in amino acid metabolism. Amino acid detection is thus integral to the diagnosis of many hereditary metabolic diseases. The development of malignant diseases as metabolic disorders comes along with a complex dysregulation of genetic and epigenetic factors affecting metabolic enzymes...

article

Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity

Christoph Tondera, Markus Laube, Jens Pietzsch

Amino Acids > 2017 > 49 > 1 > 183-191

The EF-hand type calcium-binding protein S100A12 exerts numerous intra- and extracellular functions of (patho)physiological relevance. Therefore, receptors of S100A12 are of high interest for research and clinical applications. Beside the extensively studied receptor for advanced glycation endproducts (RAGE), G-protein coupled receptors and more recently, scavenger receptors are suggested to be putative...

article

Extracellular S100A4 affects endothelial cell integrity and stimulates transmigration of A375 melanoma cells

Nadine Herwig, Birgit Belter, Jens Pietzsch

Biochemical and Biophysical Research Communications > 2016 > 477 > 4 > 963-969

High extracellular S100A4 level proves a specific characteristic of some cancer cases, including malignant melanoma. Concerning the latter, extracellular S100A4 in an autocrine manner was shown to promote prometastatic activation of A375 cells by interaction with the receptor for advanced glycation endproducts (RAGE). We hypothesized that interaction of extracellular S100A4 with RAGE in a paracrine...

article

Radiopharmacological characterization of ⁶⁴Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma

Feng Gao, Wiebke Sihver, Christoph Jurischka, Ralf Bergmann, more

Amino Acids > 2016 > 48 > 3 > 833-847

The melanocortin-1 receptor (MC1R) plays an important role in melanoma growth, angiogenesis and metastasis, and is overexpressed in melanoma cells. α-Melanocyte stimulating hormone (α-MSH) and derivatives are known to bind with high affinity at this receptor that provides the potential for selective targeting of melanoma. In this study, one linear α-MSH-derived peptide Nle-Asp-His-D-Phe-Arg-Trp-Gly-NH...

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INFONA - science communication portal

Search results for: Jens Pietzsch

Shell engineering in soft alginate‐based capsules for culturing liver spheroids

A Self‐Assembled Matrix System for Cell‐Bioengineering Applications in Different Dimensions, Scales, and Geometries

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas

Active Tumor Targeting: Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging (Small 7/2020)

Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging

Radiochemical and radiopharmacological characterization of a ⁶⁴Cu‐labeled α‐MSH analog conjugated with different chelators

Synthesis and preliminary radiopharmacological characterisation of an ¹¹C‐labelled azadipeptide nitrile as potential PET tracer for imaging of cysteine cathepsins

Instant kit preparation of ⁶⁸Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [⁶⁸Ga]Ga-DATA-TOC

Synthesis, ¹⁸F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide

Exploring pitfalls of ⁶⁴Cu-labeled EGFR-targeting peptide GE11 as a potential PET tracer

An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment

Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor

Biological characterization of novel nitroimidazole‐peptide conjugates in vitro and in vivo

In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide–Oligosaccharide Interaction in Immunocompetent Nude Mice

Human Endothelial Cell Models in Biomaterial Research

The why and how of amino acid analytics in cancer diagnostics and therapy

Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity

Extracellular S100A4 affects endothelial cell integrity and stimulates transmigration of A375 melanoma cells

Radiopharmacological characterization of ⁶⁴Cu-labeled α-MSH analogs for potential use in imaging of malignant melanoma

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