Search results for: Wim E. Hennink

Items from 1 to 20 out of 299 results

article

Inhibition of cow’s milk allergy development in mice by oral delivery of β‐lactoglobulin‐derived peptides loaded PLGA nanoparticles is associated with systemic whey‐specific immune silencing

Mengshan Liu, Suzan Thijssen, Cornelus F. Nostrum, Wim E. Hennink, more

Clinical & Experimental Allergy > 52 > 1 > 137 - 148

Background Two to four percentage of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolysed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high‐risk non‐exclusively breastfed infants. Therefore,...

article

Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges

Tarun Ojha, Qizhi Hu, Claudio Colombo, Jan Wit, more

Biotechnology Journal > 16 > 6 > n/a - n/a

Background CriPec technology enables the generation of drug‐entrapped biodegradable core‐crosslinked polymeric micelles (CCPM) with high drug loading capacity, tailorable size, and drug release kinetics. Docetaxel (DTX)‐entrapped CCPM, also referred to as CPC634, have demonstrated favorable pharmacokinetics, tolerability, and enhanced tumor uptake in patients. Clinical efficacy evaluation is ongoing...

article

A Ninhydrin‐Type Urea Sorbent for the Development of a Wearable Artificial Kidney

Jacobus A. W. Jong, Yong Guo, Diënty Hazenbrink, Stefania Douka, more

Macromolecular Bioscience > 20 > 3 > n/a - n/a

The aim of this study is to develop polymeric chemisorbents with a high density of ninhydrin groups, able to covalently bind urea under physiological conditions and thus potentially suitable for use in a wearable artificial kidney. Macroporous beads are prepared by suspension polymerization of 5‐vinyl‐1‐indanone (vinylindanone) using a 90:10 (v/v) mixture of toluene and nitrobenzene as a porogen....

article

In situ forming hydrogel for sustained intraocular drug delivery

Blessing C. Ilochonwu, Marko Mihajlovic, Miao Tang, Mei Chen, more

Acta Ophthalmologica > 97 > S263 > n/a - n/a

Purpose Delivery of therapeutic proteins to the posterior segment of the eye faces significant challenges because of frequent intraocular injections, related adverse effects and high treatment costs. This research project aims to design in situ forming hydrogels, which can be easily injected in the vitreous cavity using a small needle. After injection, the polymeric solution undergoes a phase transition...

article

RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells

Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, more

Drug Delivery and Translational Research > 2019 > 9 > 3 > 679-693

The development of an effective and safe treatment for glioblastoma (GBM) represents a significant challenge in oncology today. Downregulation of key mediators of cell signal transduction by RNA interference is considered a promising treatment strategy but requires efficient, intracellular delivery of siRNA into GBM tumor cells. Here, we describe novel polymeric siRNA nanocarriers functionalized with...

article

Mixed micellar system stabilized with saponins for oral delivery of vitamin K

Feilong Sun, Chengpei Ye, Kaushik Thanki, Donglei Leng, more

Colloids and Surfaces B: Biointerfaces > 2018 > 170 > C > 521-528

Poorly soluble vitamin K cannot be absorbed by patients suffering from cholestasis due to extremely low level of bile salts in the intestine. A formulation of vitamin K including glycocholic acid (i.e. Konakion® MM), does not increase bioavailability because it is unstable due to protonation of glycocholic acid at gastric pH. To develop a stable formulation, saponins were introduced as neutral surfactants...

article

E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells

Shima Gholizadeh, Ganesh Ram R. Visweswaran, Gert Storm, Wim E. Hennink, more

International Journal of Pharmaceutics > 2018 > 548 > 2 > 759-770

Activated endothelial cells play a pivotal role in the pathology of inflammatory disorders and thus present a target for therapeutic intervention by drugs that intervene in inflammatory signaling cascades, such as rapamycin (mammalian target of rapamycin (mTOR) inhibitor). In this study we developed anti-E-selectin immunoliposomes for targeted delivery to E-selectin over-expressing tumor necrosis...

article

Fabrication and characterization of gefitinib-releasing polyurethane foam as a coating for drug-eluting stent in the treatment of bronchotracheal cancer

Weiluan Chen, Chiara di Carlo, Donal Devery, Donnacha J. McGrath, more

International Journal of Pharmaceutics > 2018 > 548 > 2 > 803-811

The purpose of the present study was to develop gefitinib-loaded polymeric foams that can be used as coating of drug-eluting stents for palliative treatment of bronchotracheal cancer. Release of such an anticancer drug from such stent coating can retard tumor regrowth into the bronchial lumen. Gefitinib-loaded polyurethane (PU) foams were prepared by embedding either gefitinib micronized crystals...

article

PLGA-PEG nanoparticles for targeted delivery of the mTOR/PI3kinase inhibitor dactolisib to inflamed endothelium

Shima Gholizadeh, Jan. A.A.M. Kamps, Wim E. Hennink, Robbert J. Kok

International Journal of Pharmaceutics > 2018 > 548 > 2 > 747-758

Dactolisib (NVP-BEZ235, also referred to as: ′BEZ235′ or ′BEZ′) is a dual mTOR/PI3K inhibitor that is of potential interest in the treatment of inflammatory disorders. This work focuses on formulation of BEZ-loaded polymeric nanoparticles composed of a blend of poly(D,L-lactide-co-glycolide) (PLGA) and poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-2000 (PLGA-PEG). The nanoparticles were prepared...

article

Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties

Bo Lou, Ans De Beuckelaer, George R. Dakwar, Katrien Remaut, more

Journal of Controlled Release > 2018 > 284 > C > 73-83

Potent adjuvants are highly demanded for most protein and peptides based vaccine candidates in clinical development. Recognition of viral single stranded (ss)RNA by innate toll-like receptors 7/8 in dendritic cells results in a cytokine environment supportive to the establishment of long lasting antibody responses and Th1 oriented T cell immunity. To fully exploit the immunestimulatory properties...

article

The Use of Magnetic Resonance Imaging for Non-Invasive Assessment of Venofer® Biodistribution in Rats

Kimberley Span, Ebel H. E. Pieters, Wim E. Hennink, Annette Toorn, more

Pharmaceutical Research > 2018 > 35 > 4 > 1-12

Purpose The aim of this study was to determine the potential of magnetic resonance imaging to evaluate the biodistribution of exogenous iron within 24 h after one single injection of Venofer® (iron sucrose). Methods Venofer® was evaluated in vitro for its ability to generate contrast in MR images. Subsequently, iron disposition was assessed in rats with MRI, in vivo up to 3 h and post mortem at...

article

Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells

Shima Gholizadeh, Emmy M. Dolman, Rebecca Wieriks, Rolf W. Sparidans, more

Pharmaceutical Research > 2018 > 35 > 4 > 1-15

Purpose Sepantronium bromide (YM155) is a hydrophilic quaternary compound that cannot be administered orally due to its low oral bioavailability; it is furthermore rapidly eliminated via the kidneys. The current study aims at improving the pharmacokinetic profile of YM155 by its formulation in immunoliposomes that can achieve its enhanced delivery into tumor tissue and facilitate uptake in neuroblastoma...

article

In Vitro Evaluation of Anti‐Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions

Yinan Chen, George R. Dakwar, Kevin Braeckmans, Twan Lammers, more

Macromolecular Bioscience > 18 > 1 > n/a - n/a

The in vivo stability and biodegradability of nanocarriers crucially determine therapeutic efficacy as well as safety when used for drug delivery. This study aims to evaluate optimized in vitro techniques predictive for in vivo nanocarrier behavior. Polymeric biodegradable nanogels based on hydroxyethyl methacrylamide‐oligoglycolates‐derivatized poly(hydroxyethyl methacrylamide‐co‐N‐(2‐azidoethyl)methacrylamide)...

article

PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention

Atanaska I. Kostadinova, Jim Middelburg, Michele Ciulla, Johan Garssen, more

European Journal of Pharmacology > 2018 > 818 > C > 211-220

Beta-lactoglobulin (BLG)-derived peptides may facilitate oral tolerance to whey and prevent cow's milk allergy (CMA). Loading of BLG-peptides in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Pep-NP) may improve this. Here we studied the uptake of NP and the capacity of NP and Pep-NP to activate bone marrow dendritic cells (BMDC). Furthermore, CMA prevention was evaluated by orally exposing three-week-old...

article

Biodegradable Sensors: Biodegradable Microparticles for Simultaneous Detection of Counterfeit and Deteriorated Edible Products (Small 39/2017)

Ivan Rehor, Sophie van Vreeswijk, Tina Vermonden, Wim E. Hennink, more

Small > 13 > 39 > n/a - n/a

In article number 1701804, Huseyin Burak Eral and co‐workers report biodegradable hydrogel microparticles that provide information on authenticity and potential deterioration of tagged food or pharmaceutical formulations. The authenticity code and the sensor information are read with a standard microscope which enables verification of the product safety directly prior to consumption to protect consumers...

article

Biodegradable Microparticles for Simultaneous Detection of Counterfeit and Deteriorated Edible Products

Ivan Rehor, Sophie van Vreeswijk, Tina Vermonden, Wim E. Hennink, more

Small > 13 > 39 > n/a - n/a

In an era of globalized trade relations where food and pharmaceutical products cross borders effortlessly, consumers face counterfeit and deteriorated products at elevated rates. This paper presents multifunctional, biodegradable hydrogel microparticles that can provide information on the authenticity and the potential deterioration of the tagged food or pharmaceutical formulations. These microparticles...

article

Lipogels responsive to near-infrared light for the triggered release of therapeutic agents

Francisco Martín-Saavedra, Eduardo Ruiz-Hernández, Clara Escudero-Duch, Martín Prieto, more

Acta Biomaterialia > 2017 > 61 > C > 54-65

Here we report a composite system based on fibrin hydrogels that incorporate in their structure near-infrared (NIR) responsive nanomaterials and thermosensitive liposomes (TSL). Polymerized fibrin networks entrap simultaneously gold-based nanoparticles (NPs) capable of transducing NIR photon energy into heat, and lysolipid-incorporated TSL (LTSL) loaded with doxorubicin hydrochloride (DOX). NIR irradiation...

article

Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases

Jos W.H. Wennink, Yanna Liu, Petri I. Mäkinen, Francesca Setaro, more

European Journal of Pharmaceutical Sciences > 2017 > 107 > C > 112-125

Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be suitable as photosensitizer for this application, as it is currently used in the clinic for cancer PDT. In the present study, mTHPC was encapsulated in polymeric micelles based on benzyl-poly(ε-caprolactone)-b-methoxy...

article

A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis

Amr Alaarg, Max L. Senders, Aida Varela-Moreira, Carlos Pérez-Medina, more

Journal of Controlled Release > 2017 > 262 > C > 47-57

Atherosclerosis is a leading cause of worldwide morbidity and mortality whose management could benefit from novel targeted therapeutics. Nanoparticles are emerging as targeted drug delivery systems in chronic inflammatory disorders. To optimally exploit nanomedicines, understanding their biological behavior is crucial for further development of clinically relevant and efficacious nanotherapeutics...

article

Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors

Tarun Ojha, Vertika Pathak, Yang Shi, Wim E. Hennink, more

Advanced Drug Delivery Reviews > 2017 > 119 > C > 44-60

The performance of nanomedicine formulations depends on the Enhanced Permeability and Retention (EPR) effect. Prototypic nanomedicine-based drug delivery systems, such as liposomes, polymers and micelles, aim to exploit the EPR effect to accumulate at pathological sites, to thereby improve the balance between drug efficacy and toxicity. Thus far, however, tumor-targeted nanomedicines have not yet...

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INFONA - science communication portal

Search results for: Wim E. Hennink

Inhibition of cow’s milk allergy development in mice by oral delivery of β‐lactoglobulin‐derived peptides loaded PLGA nanoparticles is associated with systemic whey‐specific immune silencing

Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges

A Ninhydrin‐Type Urea Sorbent for the Development of a Wearable Artificial Kidney

In situ forming hydrogel for sustained intraocular drug delivery

RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells

Mixed micellar system stabilized with saponins for oral delivery of vitamin K

E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells

Fabrication and characterization of gefitinib-releasing polyurethane foam as a coating for drug-eluting stent in the treatment of bronchotracheal cancer

PLGA-PEG nanoparticles for targeted delivery of the mTOR/PI3kinase inhibitor dactolisib to inflamed endothelium

Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties

The Use of Magnetic Resonance Imaging for Non-Invasive Assessment of Venofer® Biodistribution in Rats

Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells

In Vitro Evaluation of Anti‐Aggregation and Degradation Behavior of PEGylated Polymeric Nanogels under In Vivo Like Conditions

PLGA nanoparticles loaded with beta-lactoglobulin-derived peptides modulate mucosal immunity and may facilitate cow's milk allergy prevention

Biodegradable Sensors: Biodegradable Microparticles for Simultaneous Detection of Counterfeit and Deteriorated Edible Products (Small 39/2017)

Biodegradable Microparticles for Simultaneous Detection of Counterfeit and Deteriorated Edible Products

Lipogels responsive to near-infrared light for the triggered release of therapeutic agents

Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases

A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis

Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors

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