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Background informationConsidering an analogy between wound healing and tumour progression, we studied chemokine and cytokine transcription and expression in normal fibroblasts by co‐culture and in situ.
ResultsWhole‐genome transcriptome profiling revealed strong upregulation for the interleukin (IL)‐6, IL‐8 and the chemokine CXCL‐1 in in vitro co‐cultures of normal fibroblasts with either normal...
Nuclear presence of galectins suggests a role of these endogenous lectins in the regulation of transcription, pre-mRNA splicing and transport processes. Therefore, detection and localization of nuclear binding sites for galectins by a new methodological step, has potential to further functional analysis. In the first step of our model study we monitored the nuclear expression of galectins-1 and -3...
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