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BEAMing (beads, emulsion, amplification, and magnetics) is a high sensitive emulsion digital PCR (polymerase chain reaction) technology. Target beads obtained via BEAMing can be used to determine the copy number of target DNA population. However, the existing beads counting process requires specialized instrument, which has increased the detection costs. Here we developed an easy and low cost beads...
Ambulatory electrocardiogram (AECG) is widely used for heart disease diagnosis and treatment after surgery, but the signal quality will be negatively affected by the motion artifact (MA) coupling in the AECG signal. Adaptive filter (AF) has been used to suppress MA from AECG. Unfortunately, because of the non-stationary property of AECG and MA, the distortion and the artifact suppression performance...
In this study, arrays of controllable, Ge-SiO2 core-shell structure nanowire (NW) were fabricated by combining the complementary metal-oxide semiconductor (CMOS) compatible technology and Ge-condensation technology. Meanwhile, based on this novel nanostructure, the biosensor application in label-free, highly sensitive detection of lung cancer biomarker was investigated. This nanosensor illuminated...
In droplet-based microfluidics, adding reagents into drops is one of the most important functions. In this paper, we develop a new picoinjector to add controlled volumes of reagent into droplets at kilohertz rates. In the new picoinjector, the adding process is triggered by the coming droplet itself, and the dosing volume can be precisely controlled. Meanwhile, the trigger voltage is lowered to several...
In ambulatory electrocardiography recording, the motion artifact can contaminate the signal and disrupt the normal functioning of the automatic analysis algorithm. The objective of this study is to evaluate an approach for measuring the electrode tissue impedance (ETI) variation for motion artifacts suppression application. The proposed approach injects an additional common mode signal though the...
This paper proposes a novel technology to fabricate 3D curved structures on SU-8 resist by a photo-acid-diffusion process. This technology deliberately modifies the standard SU-8 photolithography procedure and allows the diffusion of photo-acid released from UV-exposed regions into the adjacent unexposed resist regions, which would result in forming smooth 3D curved structures after cross-linking...
In order to enable electrode sites to get closer to target neurons, obtain a better stimulation and minimize the electrochemical erosion of electrode, we proposed dome-shaped flexible neural microelectrode arrays (MEAs) for neural applications. With the use of photosensitive polyimide (Durimide 7510, PI) as substrate, a flexible microelectrode with 6 × 6 array of dome-shaped electrode sites was fabricated...
This study reports on the development of a novel perfusion microfluidic cell culture device integrated drug delivering, fluid controlling and cell culturing functions on a two- layer PDMS chip. The device consists of an array of 6 X 6 cell culture chambers, a drug gradient generator and two control valves. Cells are physically trapped and cultured in the center of the chamber by a C-shaped dam when...
Microelectrode arrays (MEAs) have become key components in retinal implants for recording of neural signals or electrical stimulation of nerves. In this paper, implantable flexible MEAs based on a novel polymer, parylene, were developed by designing MEMS process. And electrical performance of prepared microelectrodes was characterized electrochemically. Results showed that impedance and phase delay...
This paper reports on polymer solid microneedles with pyramid-shaped tips and titanium shields for transdermal transportation of drug molecules, bio-macromolecules, or nano-particles. Microelectromechanical system (MEMS) techniques, such as masking, etching, alignment, development, sputtering, were adapted to produce polymer microneedles with sharp tips to reduce the force to pierce into skin. Polymer...
An integrated microfluidic device with on-chip performance of cell lysis, DNA extraction and PCR amplification is achieved to realize the total analysis from cell lysis to DNA amplification on a single Polydimethylsiloxane (PDMS) chip. Using multilayered PDMS patterning and Solid Phase Extraction (SPE) techniques, DNA is extracted by magnetic beads (MBs) from the cell lysate prepared by a two-step...
Fraction collection following DNA electrophoresis has many applications in biology analysis. These assays typically need to identify specific DNA fragments in the separated sample for further processing and require extraction of one or a group of fragments. Unfortunately, the conventional methods involve cumbersome procedure and are not amenable to integration, automation and extraction of microscale...
The paper proposes a novel design concept and fabrication method of micro dispensing chip. The filling process is performed by capillary force without extra energy, greatly reducing the complexity of design and operation. The annular interspaces around the nozzles in the chip can help the droplet formation on the hydrophilic surfaces, and the step conjunction between the channel and the reservoir...
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