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After realizing mirror‐image genetic replication, transcription, and reverse transcription, the biggest challenge in establishing a mirror‐image version of the central dogma is to build a mirror‐image ribosome‐based translation machine. Here, we chemically synthesized the natural and mirror‐image versions of three ribosomal proteins (L5, L18, and L25) in the large subunit of the Escherichia coli ribosome...
Schau genau hin: Ein Paar enantiomerer Liganden hatte unerwartet ähnliche Bindungsaffinitäten für Acetylcholinesterase. Die Enantiomeren wiesen verschiedene thermodynamische Profile auf, und die Analyse der nichtkovalenten Wechselwirkungen in den Protein‐Ligand‐Komplexen offenbarte, dass diese Unterschiede zum Teil auf nichtklassische Wasserstoffbrücken zwischen den Liganden und aromatischen Seitenketten...
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