Search results for: Paul A. Garris

Items from 1 to 20 out of 29 results

chapter

On the use of compressive sensing (CS) for brain dopamine recording with fast-scan cyclic voltammetry (FSCV)

Hossein Zamani, Hamid Bahrami, Paul A. Garris, Pedram Mohseni

2017 IEEE International Symposium on Circuits and Systems (ISCAS) > 1 - 4

2017 IEEE International Symposium on Circuits and Systems (ISCAS)

This paper presents a novel compressive sensing (CS) framework for recording of electrically evoked brain dopamine levels using fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM). This approach utilizes the discrete cosine transform (DCT) as the sparsifying domain for the background-subtracted faradaic (dopamine) currents, along with the block sparse Bayesian learning (BSBL)...

article

Amphetamine elevates nucleus accumbens dopamine via an action potential‐dependent mechanism that is modulated by endocannabinoids

Dan P. Covey, Kendra D. Bunner, Douglas R. Schuweiler, Joseph F. Cheer, more

European Journal of Neuroscience > 43 > 12 > 1661 - 1673

The reinforcing effects of abused drugs are mediated by their ability to elevate nucleus accumbens dopamine. Amphetamine (AMPH) was historically thought to increase dopamine by an action potential‐independent, non‐exocytotic type of release called efflux, involving reversal of dopamine transporter function and driven by vesicular dopamine depletion. Growing evidence suggests that AMPH also acts by...

article

Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine

Bardia Bozorgzadeh, Douglas R. Schuweiler, Martin J. Bobak, Paul A. Garris, more

IEEE Transactions on Biomedical Circuits and Systems > 2016 > 10 > 3 > 654 - 667

This paper presents a $3.3\times 3.2\ {\rm mm}^{2}$ system-on-chip (SoC) fabricated in AMS 0.35 $\mu{\rm m}$ 2P/4M CMOS for closed-loop regulation of brain dopamine. The SoC uniquely integrates neurochemical sensing, on-the-fly chemometrics, and feedback-controlled electrical stimulation to realize a “neurochemostat” by maintaining brain levels of electrically evoked dopamine between two user-set thresholds...

chapter

FPGA implementation of principal component regression (PCR) for real-time differentiation of dopamine from interferents

Bardia Bozorgzadeh, Daniel P. Covey, Paul A. Garris, Pedram Mohseni

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) > 5151 - 5154

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

This paper reports on field-programmable gate array (FPGA) implementation of a digital signal processing (DSP) unit for real-time processing of neurochemical data obtained by fast-scan cyclic voltammetry (FSCV) at a carbonfiber microelectrode (CFM). The DSP unit comprises a decimation filter and two embedded processors to process the FSCV data obtained by an oversampling recording front-end and differentiate...

article

Real-time monitoring of electrically evoked catecholamine signals in the songbird striatum using in vivo fast-scan cyclic voltammetry

Amanda R. Smith, Paul A. Garris, Joseph M. Casto

Journal of Chemical Neuroanatomy > 2015 > 66-67 > Complete > 28-39

Fast-scan cyclic voltammetry is a powerful technique for monitoring rapid changes in extracellular neurotransmitter levels in the brain. In vivo fast-scan cyclic voltammetry has been used extensively in mammalian models to characterize dopamine signals in both anesthetized and awake preparations, but has yet to be applied to a non-mammalian vertebrate. The goal of this study was to establish in vivo...

chapter

Neurochemical thermostat: A neural interface SoC with integrated chemometrics for closed-loop regulation of brain dopamine

Bardia Bozorgzadeh, Douglas Schuweiler, Martin Bobak, Paul A. Garris, more

2015 Symposium on VLSI Circuits (VLSI Circuits) > C110 - C111

2015 Symposium on VLSI Circuits

A 3.3 × 3.2mm² SoC in 0.35μm 2P/4M CMOS combines neurochemical sensing, on-the-fly chemometrics, and feedback-controlled stimulation to realize a “neurochemical thermostat” by differentiating electrically evoked brain dopamine levels from interferents in complex signals recorded in vivo and maintaining the levels between two user-set thresholds via closed-loop neuromodulation. The SoC features duty...

chapter

Real-time processing of fast-scan cyclic voltammetry (FSCV) data using a field-programmable gate array (FPGA)

Bardia Bozorgzadeh, Daniel P. Covey, Byron A. Heidenreich, Paul A. Garris, more

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society > 2036 - 2039

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

This paper reports the hardware implementation of a digital signal processing (DSP) unit for real-time processing of data obtained by fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM), an electrochemical transduction technique for high-resolution monitoring of brain neurochemistry. Implemented on a field-programmable gate array (FPGA), the DSP unit comprises a decimation filter...

article

Illicit dopamine transients: Reconciling actions of abused drugs

Dan P. Covey, Mitchell F. Roitman, Paul A. Garris

Trends in Neurosciences > 2014 > 37 > 4 > 200-210

Phasic increases in brain dopamine are required for cue-directed reward seeking. Although compelling within the framework of appetitive behavior, the view that illicit drugs hijack reward circuits by hyperactivating these dopamine transients is inconsistent with established psychostimulant pharmacology. However, recent work reclassifying amphetamine (AMPH), cocaine, and other addictive dopamine-transporter...

article

A Neurochemical Pattern Generator SoC With Switched-Electrode Management for Single-Chip Electrical Stimulation and 9.3 µW, 78 pA rms , 400 V/s FSCV Sensing

Bardia Bozorgzadeh, Daniel P. Covey, Christopher D. Howard, Paul A. Garris, more

IEEE Journal of Solid-State Circuits > 2014 > 49 > 4 > 881 - 895

This paper describes a system-on-chip (SoC) fabricated in AMS 0.35 µm 2P/4M CMOS for high-fidelity neurochemical pattern generation in vivo. The SoC uniquely integrates electrical stimulation with embedded timing management for generation of neurochemical patterns and 400 V/s fast-scan cyclic voltammetry (FSCV) sensing for subsequent assessment of fidelity in the generated profiles, and manages a...

article

Methamphetamine-Induced Neurotoxicity Disrupts Pharmacologically Evoked Dopamine Transients in the Dorsomedial and Dorsolateral Striatum

John D. Robinson, Christopher D. Howard, Elissa D. Pastuzyn, Diane L. Byers, more

Neurotoxicity Research > 2014 > 26 > 2 > 152-167

Phasic dopamine (DA) signaling, during which burst firing by DA neurons generates short-lived elevations in extracellular DA in terminal fields called DA transients, is implicated in reinforcement learning. Disrupted phasic DA signaling is proposed to link DA depletions and cognitive-behavioral impairment in methamphetamine (METH)-induced neurotoxicity. Here, we further investigated this disruption...

article

Methamphetamine‐induced neurotoxicity disrupts naturally occurring phasic dopamine signaling

Christopher D. Howard, David P. Daberkow, Eric S. Ramsson, Kristen A. Keefe, more

European Journal of Neuroscience > 38 > 1 > 2078 - 2088

Methamphetamine (METH) is a highly addictive drug that is also neurotoxic to central dopamine (DA) systems. Although striatal DA depletions induced by METH are associated with behavioral and cognitive impairments, the link between these phenomena remains poorly understood. Previous work in both METH‐pretreated animals and the 6‐hydroxydopamine model of Parkinson's disease suggests that a disruption...

article

Phasic‐like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine‐induced partial dopamine denervation

Christopher D. Howard, Elissa D. Pastuzyn, Melissa L. Barker‐Haliski, Paul A. Garris, more

Journal of Neurochemistry > 125 > 4 > 555 - 565

Methamphetamine‐induced partial dopamine depletions are associated with impaired basal ganglia function, including decreased preprotachykinin mRNA expression and impaired transcriptional activation of activity‐regulated, cytoskeleton‐associated (Arc) gene in striatum. Recent work implicates deficits in phasic dopamine signaling as a potential mechanism linking methamphetamine‐induced dopamine loss...

article

Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms

Alicia J. Avelar, Steven A. Juliano, Paul A. Garris

Journal of Neurochemistry > 125 > 3 > 373 - 385

Amphetamine has well‐established actions on pre‐synaptic dopamine signaling, such as inhibiting uptake and degradation, activating synthesis, depleting vesicular stores, and promoting dopamine‐transporter reversal and non‐exocytotic release. Recent in vivo studies have identified an additional mechanism: augmenting vesicular release. In this study, we investigated how amphetamine elicits this effect...

chapter

A neurochemical pattern generator SoC with switched-electrode management for single-chip electrical stimulation and 9.3µW, 78pA_rms, 400V/s FSCV sensing

Bardia Bozorgzadeh, Daniel P. Covey, Christopher D. Howard, Paul A. Garris, more

2013 Symposium on VLSI Circuits > C50 - C51

2013 Symposium on VLSI Circuits

This paper describes a system-on-chip (SoC) fabricated in 0.35µm 2P/4M CMOS for high-fidelity neurochemical pattern generation in vivo. The SoC uniquely integrates electrical stimulation with embedded timing management and 400V/s fast-scan cyclic voltammetry (FSCV) sensing, and manages a novel switched-electrode scheme that eliminates the possibility of large stimulus artifacts adversely affecting...

article

Wireless Fast-Scan Cyclic Voltammetry to Monitor Adenosine in Patients With Essential Tremor During Deep Brain Stimulation

Su-Youne Chang, Inyong Kim, Michael P. Marsh, Dong Pyo Jang, more

Mayo Clinic Proceedings > 2012 > 87 > 8 > 760-765

Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility...

article

High doses of amphetamine augment, rather than disrupt, exocytotic dopamine release in the dorsal and ventral striatum of the anesthetized rat

Eric S. Ramsson, Christopher D. Howard, Dan P. Covey, Paul A. Garris

Journal of Neurochemistry > 119 > 6 > 1162 - 1172

J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07407.x AbstractHigh doses of amphetamine (AMPH) are thought to disrupt normal patterns of action potential‐dependent dopaminergic neurotransmission by depleting vesicular stores of dopamine (DA) and inducing robust non‐exocytotic DA release or efflux via dopamine transporter (DAT) reversal. However, these cardinal AMPH actions have been difficult to...

article

Methamphetamine neurotoxicity decreases phasic, but not tonic, dopaminergic signaling in the rat striatum

Christopher D. Howard, Kristen A. Keefe, Paul A. Garris, David P. Daberkow

Journal of Neurochemistry > 118 > 4 > 668 - 676

J. Neurochem. (2011) 118, 668–676. AbstractNeurotoxic doses of methamphetamine (METH) are known to cause depletions in striatal dopamine (DA) tissue content. However, the effects of METH‐induced insults on dopaminergic neurotransmission are not fully understood. Here, we employed fast‐scan cyclic voltammetry at a carbon‐fiber microelectrode in the anesthetized rat striatum to assess the effects of...

article

Amphetamine augments action potential‐dependent dopaminergic signaling in the striatum in vivo

Eric S. Ramsson, Daniel P. Covey, David P. Daberkow, Melissa T. Litherland, more

Journal of Neurochemistry > 117 > 6 > 937 - 948

J. Neurochem. (2011) 117, 937–948. AbstractAmphetamine (AMPH) is thought to disrupt normal patterns of action potential‐dependent dopaminergic signaling by depleting dopamine (DA) vesicular stores and promoting non‐exocytotic DA efflux. Voltammetry in brain slices concurrently demonstrates these key drug effects, along with competitive inhibition of neuronal DA uptake. Here, we perform comparable...

article

Voltammetric measurement of electrically evoked dopamine levels in the striatum of the anesthetized Syrian hamster

Phillip G. Greco, Robert L. Meisel, Byron A. Heidenreich, Paul A. Garris

Journal of Neuroscience Methods > 2006 > 152 > 1-2 > 55-64

Microdialysis measurements in the Syrian hamster clearly demonstrate a role for accumbal dopamine (DA) in female sexual behavior. However, large probe size and slow sampling rate prevent associating specific behaviors with DA changes in subregions of the heterogeneous nucleus accumbens. Fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM), which affords millisecond temporal resolution...

article

Scanning Electrochemical Microscopy of Model Neurons: Constant Distance Imaging

Ruwan T. Kurulugama, David O. Wipf, Sara A. Takacs, Sirinun Pongmayteegul, more

Analytical Chemistry > 2005 > 77 > 4 > 1111 - 1117

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DOPAMINE (16)
VOLTAMMETRY (14)
POWER CAPACITORS (6)
SENSORS (6)
NUCLEUS ACCUMBENS (5)
RELEASE (5)
ELECTRICAL STIMULATION (4)
RAT (4)
SYSTEM-ON-CHIP (4)
UPTAKE (4)
AMPHETAMINE (3)
CAUDATE-PUTAMEN (3)
CURRENT MEASUREMENT (3)
METHAMPHETAMINE (3)
NEUROCHEMICAL SENSING (3)
VENTRAL MESENCEPHALON (3)
DIGITAL SIGNAL PROCESSING (2)
EFFLUX (2)
FAST-SCAN CYCLIC VOLTAMMETRY (2)
NEUROMODULATION (2)
PATTERN GENERATION (2)
REAL-TIME SYSTEMS (2)
STRIATUM (2)
TIMING (2)
TRANSIENT (2)
6-OHDA (1)
ARC (1)
BEHAVIOR (1)
BLUETOOTH (1)
BRAIN REWARD SYSTEM (1)
BRAIN-MACHINE-BRAIN INTERFACE (1)
CARBON-FIBER MICROELECTRODE (1)
CAUDATE PUTAMEN (1)
CHEMOMETRICS (1)
CLOSED-LOOP NEUROMODULATION (1)
CMOS INTEGRATED CIRCUITS (1)
COCAINE (1)
COMPUTER ARCHITECTURE (1)
DAT (DOPAMINE TRANSPORTER) (1)
DEGRADATION (1)
DICTIONARIES (1)
DIFFUSION (1)
DIGITAL SIGNAL PROCESSOR (1)
DISCRETE COSINE TRANSFORMS (1)
DOPAMINE REGULATION (1)
ELECTROPHYSIOLOGY (1)
ENDOCANNABINOIDS (1)
EUROPEAN STARLING (1)
EXOCYTOSIS (1)
EXPERIMENTER APPLIED STIMULATION (1)
FIELD PROGRAMMABLE GATE ARRAYS (1)
FINITE IMPULSE RESPONSE FILTERS (1)
IN VIVO (1)
INTERFERENT DIFFERENTIATION (1)
INTRACRANIAL STIMULATION (1)
LOCOMOTOR ACTIVITY (1)
MEDIAL FOREBRAIN BUNDLE (1)
MESOLIMBIC (1)
NEUROTOXICITY (1)
NON-CONTINGENT BRAIN STIMULATION (1)
NON-CONTINGENT EXPERIMENTER-APPLIED STIMULATION (1)
NOREPINEPHRINE (1)
OXIDATION (1)
PARKINSON'S DISEASE (1)
PHASIC (1)
PREPROTACHYKININ (1)
PRINCIPAL COMPONENT REGRESSION (1)
PROGRAM PROCESSORS (1)
PSYCHOMOTOR STIMULANT (1)
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RATS (1)
SIGNAL RECONSTRUCTION (1)
SWITCHES (1)
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SYRIAN HAMSTER (1)
TELEMETRY (1)
THERMOSTATS (1)
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TRAINING (1)
TRANSFER FUNCTIONS (1)
TRIPOLAR STIMULATING ELECTRODE (1)
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European Journal of Neuroscience (2)
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European Journal of Pharmacology (1)
IEEE Journal of Solid-State Circuits (1)
IEEE Transactions on Biomedical Circuits and Systems (1)
Journal of Chemical Neuroanatomy (1)
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INFONA - science communication portal

Search results for: Paul A. Garris

On the use of compressive sensing (CS) for brain dopamine recording with fast-scan cyclic voltammetry (FSCV)

Amphetamine elevates nucleus accumbens dopamine via an action potential‐dependent mechanism that is modulated by endocannabinoids

Neurochemostat: A Neural Interface SoC With Integrated Chemometrics for Closed-Loop Regulation of Brain Dopamine

FPGA implementation of principal component regression (PCR) for real-time differentiation of dopamine from interferents

Real-time monitoring of electrically evoked catecholamine signals in the songbird striatum using in vivo fast-scan cyclic voltammetry

Neurochemical thermostat: A neural interface SoC with integrated chemometrics for closed-loop regulation of brain dopamine

Real-time processing of fast-scan cyclic voltammetry (FSCV) data using a field-programmable gate array (FPGA)

Illicit dopamine transients: Reconciling actions of abused drugs

A Neurochemical Pattern Generator SoC With Switched-Electrode Management for Single-Chip Electrical Stimulation and 9.3 µW, 78 pA rms , 400 V/s FSCV Sensing

Methamphetamine-Induced Neurotoxicity Disrupts Pharmacologically Evoked Dopamine Transients in the Dorsomedial and Dorsolateral Striatum

Methamphetamine‐induced neurotoxicity disrupts naturally occurring phasic dopamine signaling

Phasic‐like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine‐induced partial dopamine denervation

Amphetamine augments vesicular dopamine release in the dorsal and ventral striatum through different mechanisms

A neurochemical pattern generator SoC with switched-electrode management for single-chip electrical stimulation and 9.3µW, 78pA_rms, 400V/s FSCV sensing

Wireless Fast-Scan Cyclic Voltammetry to Monitor Adenosine in Patients With Essential Tremor During Deep Brain Stimulation

High doses of amphetamine augment, rather than disrupt, exocytotic dopamine release in the dorsal and ventral striatum of the anesthetized rat

Methamphetamine neurotoxicity decreases phasic, but not tonic, dopaminergic signaling in the rat striatum

Amphetamine augments action potential‐dependent dopaminergic signaling in the striatum in vivo

Voltammetric measurement of electrically evoked dopamine levels in the striatum of the anesthetized Syrian hamster

Scanning Electrochemical Microscopy of Model Neurons: Constant Distance Imaging

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