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Hyperosmotic stress activates Na + -K + -2Cl - cotransport (NKCC1) in secretory epithelia of the airways. NKCC1 activation was studied as uptake of 36 Cl or 86 Rb in human tracheal epithelial cells (HTEC). Application of hypertonic sucrose or NaCl increased bumetanide-sensitive ion uptake but did not affect Na + /H + and Cl - ...
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