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A series of novel, highly potent _v_3 antagonists based on a benzoic acid scaffold and containing an acylguanidine as an Arg-mimetic and sulfonamide side chains is described. The compounds are selective against the fibrinogen receptor _IIb_3 and they are capable of inhibiting bone resorption in vivo in a TPTX model of osteoporosis. Therefore the compounds are promising drug substances for the treatment...
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