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Key points
A‐ and C‐nociceptors make different contributions to pain. They signal fast and slow pain, respectively, and C‐nociceptors drive central sensitisation.
Cyclooxygenase‐1 (COX‐1)‐dependent descending facilitation from the periaqueductal grey (PAG) affects C‐nociceptor spinal reflexes, but leaves A‐nociceptor reflexes largely untouched.
We studied the responses of spinal wide dynamic‐range...
Key pointsAt the heart of the brain circuitry underlying fear behaviour is the periaqueductal grey (PAG).We address an important gap in understanding regarding the neural pathways and mechanisms that link the PAG to distinct patterns of motor response associated with survival behaviours.We identify a highly localised part of the cerebellum (lateral vermal lobule VIII, pyramis) as a key supraspinal...