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The release of endogenous serotonin and dopamine from slices of mouse forebrains induced by high extracellular K + was examined in histamine H1 receptor knockout mice. The release of 5-hydroxytryptamine (5-HT) evoked by 30 mM K + significantly decreased in the presence of 10-50 μM histamine in wild-type mice, but was not inhibited in the mutant mice. Histamine H1 receptor-mediated...
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