Search results for: Markus Kornprobst
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Protein Science > 26 > 2 > 327 - 342
Ribosome biogenesis in eukaryotic cells is a highly dynamic and complex process innately linked to cell proliferation. The assembly of ribosomes is driven by a myriad of biogenesis factors that shape pre‐ribosomal particles by processing and folding the ribosomal RNA and incorporating ribosomal proteins. Biochemical approaches allowed the isolation and characterization of pre‐ribosomal particles from...
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The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional ribosome formation, composed of ∼70 assembly factors and several small nucleolar RNAs (snoRNAs) that associate with nascent pre-rRNA. We report the cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome, revealing how a network of biogenesis factors including 19 β-propellers and large α-solenoid proteins...
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Government and Opposition > 47 > 3 > 275 - 295
Compromise is routinely evoked in everyday language and in scholarly debates across the social sciences. Yet, it has been subjected to relatively little systematic study. The introduction to this inter‐disciplinary volume addresses the research gap in three steps. First, we offer three reasons for the study of compromise: its empirical omnipresence in politics, its theoretical potential to bridge...
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Government and Opposition > 47 > 3 > 342 - 367
How do actors, once they have reached agreement on a compromise, make this compromise persist? Being rooted in mutual concessions, it can never be taken for granted that compromises, once agreed upon, stay in place. Contestation about compliance is something that is very much to be expected and does not inevitably destabilize a compromise. Whether such a destabilization occurs or not depends on how...
