To translate the recently developed PRO‐QUEST (Progressive saturation for quantifying exchange rates using saturation times) sequence from preclinical 9.4T to 3T clinical magnetic field strength.
Numerical simulations were performed to define the optimal saturation flip angles for PRO‐QUEST saturation pulses at 3T and demonstrate the effect of a ∆T2 error on the exchange rate (k...
To develop a new MRI technique to rapidly measure exchange rates in CEST MRI.
A novel pulse sequence for measuring chemical exchange rates through a progressive saturation recovery process, called PRO‐QUEST (progressive saturation for quantifying exchange rates using saturation times), has been developed. Using this method, the water magnetization is sampled under non‐steady‐state...
Chemical exchange saturation transfer (CEST) NMR or MRI experiments allow detection of low concentrated molecules with enhanced sensitivity via their proton exchange with the abundant water pool. Be it endogenous metabolites or exogenous contrast agents, an exact quantification of the actual exchange rate is required to design optimal pulse sequences and/or specific sensitive agents.
The ability to walk is critical for functional independence and wellbeing. The pre‐frontal cortex (PFC) plays a key role in cognitive control of locomotion, notably under attention‐demanding conditions. Factors that influence brain responses to cognitive demands of locomotion, however, are poorly understood. Herein, we evaluated the individual and combined effects of gender and perceived stress on...
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SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.