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Three‐dimensional (3D) tumor cell culture offers a more tissue‐recapitulating model in cancer treatment evaluation. However, conventional models based on cell‐substrate adhesion deprivation are still of insufficient real tumor mimic. In this work, a novel method is proposed for inducing multicellular spheroids (MCSs) formation based on hydrogel with tunable microenvironmental properties. Colon tumor...
Front Cover: In this artwork, a novel method for inducing multicellular spheroids (MCSs) formation is proposed based on hydrogel with tunable microenvironmental properties (the lower half of the cover design). The synergism of chemotherapeutic drugs (the bubbles around the MCSs) and noninvasive photothermal therapy based on graphene device (the upper half of the cover design) is furtherly verified...
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