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Background and Purpose
Conventional MRI measures of multiple sclerosis (MS) disease severity, such as lesion volume and brain atrophy, do not provide information about microstructural tissue changes, which may be driving physical and cognitive progression. Myelin damage in normal‐appearing white matter (NAWM) is likely an important contributor to MS disability. Myelin water fraction (MWF) provides...
BACKGROUND AND PURPOSE
Cognitive impairment is a core symptom in multiple sclerosis (MS). Damage to normal appearing white matter (NAWM) is likely involved. We sought to determine if greater myelin heterogeneity in NAWM is associated with decreased cognitive performance in MS.
METHODS
A total of 27 participants with MS and 13 controls matched for age, sex, and education underwent myelin water imaging...
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