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Abstract
The Shank proteins are crucial scaffolding elements of the post‐synaptic density (PSD). One of the best‐characterized domains in Shank is the PDZ domain, which binds to C‐terminal segments of several other PSD proteins. We carried out a detailed structural analysis of Shank3 PDZ domain‐peptide complexes, to understand determinants of binding affinity towards different ligand proteins. Ligand...