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Bis(7)-tacrine is a novel dimeric acetylcholinesterase inhibitor derived from tacrine that shows promise for the treatment of Alzheimer's disease. We have previously reported that bis(7)-tacrine inhibits GABA A receptors. In the present study we investigated the mechanism of bis(7)-tacrine inhibition of GABA A receptor function using whole-cell patch-clamp recording in cultured rat...
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