Search results for: Jiazhong Li
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Structure–activity relationship study of oxindole-based inhibitors of cyclin-dependent kinases based on least-squares support vector machines
Analytica Chimica Acta > 2007 > 581 > 2 > 333-342
The least-squares support vector machines (LS-SVMs), as an effective modified algorithm of support vector machine, was used to build structure–activity relationship (SAR) models to classify the oxindole-based inhibitors of cyclin-dependent kinases (CDKs) based on their activity. Each compound was depicted by the structural descriptors that encode constitutional, topological, geometrical, electrostatic...
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- GENETIC ALGORITHM (6)
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