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No treatment for nonalcoholic fatty liver disease (NAFLD) has been approved by regulatory agencies. We performed a randomized controlled trial to determine whether 52 weeks of cysteamine bitartrate delayed release (CBDR) reduces the severity of liver disease in children with NAFLD.We performed a double-masked trial of 169 children with NAFLD activity scores of 4 or higher at 10 centers. From June...
Background & Aims: Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate α2A adrenoreceptor, 5-HT transporter, and GNβ3 genes and weight loss with sibutramine. Methods: We conducted a randomized, double-blind, pharmacogenetic study of behavioral therapy and sibutramine (10 or 15 mg daily) or placebo for 12 weeks...
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