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Craving elicited by drug-associated cues intensifies across protracted drug abstinence – a phenomenon termed “incubation of craving” – and drug-craving in human addicts correlates with frontal cortical hyperactivity. Herein, we employed a rat model of cue-elicited cocaine-craving to test the hypothesis that the time-dependent incubation of cue-elicited cocaine-craving is associated with adaptations...
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