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This study was undertaken to evaluate whether exosomes from human adipose‐derived stem cells (ASC‐exo) can stimulate the regeneration of human dermal fibroblasts (HDFs). Immunoblotting and FACS analyses showed that ASC‐exo was positive for exosome markers. Fluorescence tracking revealed that the contents of ASC‐exo were transferred into the HDFs. ASC‐exo treatment also stimulated the proliferation...
Summary Purpose Preclinical data has demonstrated the potential of simvastatin to overcome cetuximab resistance in KRAS mutant CRC patients. Therefore, we designed a study using simvastatin/cetuximab/irinotecan for KRAS mutant CRC patients who are refractory to irinotecan and oxaliplatin-based chemotherapy. Patients and methods In this phase II study, patients received 500 mg/m2 cetuximab, 150–180 mg/m...
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