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Background
As liquid‐based cytology (LBC) specimens preserve high‐quality DNA, clinical sequencing of LBC specimens using next‐generation sequencing (NGS) is becoming a common strategy. This study aimed to evaluate the feasibility of NGS‐based custom‐made panels for evaluating MUC promoter methylation in LBC specimens.
Methods
Thirty‐one patients with pancreatic cancer were enrolled in the study...
Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1), has several pleiotropic effects. We investigated whether ghrelin induces intestinal adaptation...
Diethlstilbestrol (DES) is a synthetic estrogen prescribed to several millions of pregnant women worldwide. The risk for breast cancer after age 40 in women prenatally exposed to DES has been reported; however, the precise mechanism of susceptibility to breast cancer remains to be resolved. We investigated the global gene expression profile of terminal end buds (TEBs), the target of carcinogen, in...
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