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DNA double‐strand breaks are increased in human melanoma tissue as detected by histone H2AX phosphorylation.1–3 We investigated two of the downstream effectors of DNA double‐strand breaks, Rad50 and 53BP1 (tumor suppressor p53 binding protein 1), to determine if they are altered in human primary melanoma cells. Melanoma cases showed high Rad50 staining (81.8%; 9/11) significantly more frequently than...