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Chemical modification to produce a hydrophilic microrough titanium (Ti) implant surface has been shown to increase osseointegration compared with microrough topography alone. This study aimed to investigate the roles of PI3K/Akt signaling pathway in regulating proliferation and differentiation of osteoblasts in response to surface microroughness and hydrophilicity. Ti disks were manufactured to present...
Surface roughness of titanium‐based implants may enhance osteogenic differentiation of cells in vitro and bone‐to‐implant contact in vivo. Nevertheless, how surface roughness regulates the signaling pathway of osteoblasts is little understood. The study intended to investigate specifically the roles of extracellular signal‐regulated kinase 1/2 (ERK1/2) pathway in regulating osteogenic differentiation...
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