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BackgroundA unique type of CD11cpos dendritic cells (DC) is abundant in inflamed tissue, for example, in chronic inflammatory skin diseases. Due to their remarkable production of tumor necrosis factor (TNF)‐α and inducible NO synthase (iNOS), these cells have been referred to as TNF and iNOS‐producing DC (Tip‐DC). While Tip‐DC have been mainly characterized in murine models of infection, functional...
To cite this article: Novak N, Bieber T, Allam J‐P. Immunological mechanisms of sublingual allergen‐specific immunotherapy. Allergy 2011; 66: 733–739.
AbstractWithin the last 100 years of allergen‐specific immunotherapy, many clinical and scientific efforts have been made to establish alternative noninvasive allergen application strategies. Thus, intra‐oral allergen delivery to the sublingual mucosa...
Recent progress achieved by an impressive number of studies focusing upon the ontogenesis and immunobiology of epidermal Langerhans cells (LCs) and other cutaneous dendritic cell (DC) populations as well as DCs at oral mucosal tissue has profoundly revised our understanding of the role of DCs in different tissues and microenvironments. By sensing their environment for microbial signals or allergens...
Die atopische Dermatitis(AD) ist in den westlichen Industrieländern deutlich auf dem Vormarsch. Neue Erkenntnisse in Bezug auf die Pathogenese der Erkrankung spiegeln sich auch in einer veränderten Terminologie, vorgeschlagen von der World Allergy Organization: eine Aufteilung in eine atopische und eine nichtatopische Dermatitis. Die Pathogenese der AD, auf die sich dieser Beitrag konzentriert, ist...
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