To test whether using disease prognosis can inform a rational approach to active surveillance (AS) for early prostate cancer.
Patients and methods
We previously developed the Cambridge Prognostics Groups (CPG) classification, a five‐tiered model that uses prostate‐specific antigen (PSA), Grade Group and Stage to predict cancer survival outcomes. We applied the CPG model to a UK and a...
To assess early outcomes since the introduction of an active surveillance (AS) protocol incorporating multiparametric magnetic resonance imaging (mpMRI)‐guided baseline biopsies and image‐based surveillance.
Patients and Methods
A new AS protocol mandating image‐guided baseline biopsies, annual mpMRI and 3‐monthly prostate‐specific antigen (PSA) testing, but which retained protocol re‐biopsies,...
ObjectiveTo investigate the clinical and pathological trends, over a 10‐year period, in robot‐assisted laparoscopic prostatectomy (RALP) in a UK regional tertiary referral centre.
Patients and MethodsIn all, 1 500 consecutive patients underwent RALP between October 2005 and January 2015. Prospective data were collected on clinicopathological details at presentation as well as surgical outcomes and...
Risk‐reducing mastectomy (RRM) confers 90–95% decreased risk of breast cancer, and may reduce mortality, especially in high‐risk groups such as BRCA carriers. Risk of occult disease in RRM specimen is ~5%. This demands axillary staging: sentinel lymph node (SLN) biopsy is no longer possible, axillary clearance confers significant risks and may prove negative. Contemporaneous SLN biopsy allows axillary...
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.