Search results for: Zhixiang Wang

Items from 1 to 20 out of 81 results

article

STAT5 phosphorylation plus minimal residual disease defines a novel risk classification in adult B‐cell acute lymphoblastic leukaemia

Xiuli Xu, Zicong Huang, Chenhao Ding, Shiyu Deng, more

British Journal of Haematology > 205 > 2 > 517 - 528

The dysregulation of the Janus family tyrosine kinase‐signal transducer and activator of transcription (JAK‐STAT) is closely related to acute lymphoblastic leukaemia (ALL), whereas the clinical value of phosphorylated STAT5 (pSTAT5) remains elusive. Herein we performed a prospective study on clinical significance of flow cytometry‐based pSTAT5 in adult B‐ALL patients. A total of 184 patients were...

article

Adoptive therapy with cytomegalovirus‐specific cytotoxic T lymphocytes for refractory cytomegalovirus DNAemia and disease after allogeneic haematopoietic stem cell transplantation

Zhonghui Jiang, Zhiping Fan, Tian Zhang, Ren Lin, more

British Journal of Haematology > 204 > 4 > 1393 - 1401

Cytomegalovirus (CMV) DNAemia and disease are common complications in patients undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT). Few studies have compared the efficacy and safety of the HSCT donor and third‐party CMV‐specific cytotoxic T lymphocytes (CMV‐CTLs) in the treatment of CMV DNAemia and disease. In this study, we retrospectively compared the efficacy and safety of...

article

Real‐time auto‐segmentation of the ureter in video sequences of gynaecological laparoscopic surgery

Zhixiang Wang, Chongdong Liu, Zhen Zhang, Yupeng Deng, more

The International Journal of Medical Robotics and Computer Assisted Surgery > 20 > 1 > n/a - n/a

Background Ureteral injury is common during gynaecological laparoscopic surgery. Real‐time auto‐segmentation can assist gynaecologists in identifying the ureter and reduce intraoperative injury risk. Methods A deep learning segmentation model was crafted for ureter recognition in surgical videos, utilising 3368 frames from 11 laparoscopic surgeries. Class activation maps enhanced the model's interpretability,...

article

Idarubicin plus BuCy versus BuCy conditioning regimens for intermediate‐risk acute myeloid leukemia in first complete remission undergoing auto‐HSCT: An open‐label, multicenter, randomized phase 3 trial

Hui Liu, Fen Huang, Yu Zhang, Meiqing Wu, more

American Journal of Hematology > 98 > 3 > 408 - 412

We report a randomized prospective phase 3 study, designed to evaluate the efficacy and tolerability of idarubicin plus busulfan and cyclophosphamide (IDA‐BuCy) versus BuCy in autologous hematopoietic stem‐cell transplantation (auto‐HSCT) for intermediate‐risk acute myeloid leukemia (IR‐AML) patients in first complete remission (CR1). One hundred and fifty‐four patients were enrolled and randomized...

article

A phase 2 study of sorafenib combined with conventional therapies in refractory central nervous system leukemia

Xiaoxia Chen, Junwei Huang, Na Xu, Zhiping Fan, more

Cancer > 128 > 11 > 2138 - 2147

Background Patients with refractory central nervous system leukemia (CNSL) have a dismal prognosis and lack effective therapy. Case reports have shown that sorafenib is effective against brain metastases, including leukemia. Methods To explore the efficacy of sorafenib combined with conventional therapies for refractory CNSL, a phase 2 study was conducted. The primary end point was the complete...

article

Cidofovir, a choice for salvage treatment of cytomegalovirus infection in patients with haploidentical hematopoietic stem cell transplantation

Zhao Yin, Jing Sun, Ying Yang, Na Xu, more

Transplant Infectious Disease > 24 > 2 > n/a - n/a

Background Cidofovir (CDV) is a nucleotide analogue with broad antiviral activities. It remains unclear about the CDV administration for anti‐cytomegalovirus (CMV) treatment in patients with haploidentical hematopoietic stem cell transplantation (haplo‐HSCT). Patients and methods In this study, 31 out of 101 haplo‐HSCT recipients who suffered CMV infection in the CT group (conventional treatment)...

article

Back Cover: Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization (Angew. Chem. Int. Ed. 16/2022)

Bowei Ma, Qinqin Shi, Xiaoying Ma, Yawen Li, more

Angewandte Chemie International Edition > 61 > 16 > n/a - n/a

Defect‐free alternating conjugated polymers were produced by exploring palladium‐catalyzed Stille polymerization at room temperature. The selected copolymers demonstrated no homocoupling defects and superior charge transport properties, thus paving the road for the development of plastic electronics. Details of this study are reported by Qinqin Shi, Hui Huang, and co‐workers in their Research Article...

article

Rücktitelbild: Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization (Angew. Chem. 16/2022)

Bowei Ma, Qinqin Shi, Xiaoying Ma, Yawen Li, more

Angewandte Chemie > 134 > 16 > n/a - n/a

Defektfreie alternierende konjugierte Polymere wurden durch Pd‐katalysierte Stille‐Polymerisation bei Raumtemperatur hergestellt. Die ausgewählten Copolymere weisen keine Homokupplungsdefekte auf und zeigen hervorragende Ladungstransporteigenschaften, was einen Weg für die Entwicklung von Kunststoffelektronik aufzeigt. Einzelheiten zu dieser Studie werden im Forschungsartikel von Qinqin Shi, Hui Huang...

article

Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization

Bowei Ma, Qinqin Shi, Xiaoying Ma, Yawen Li, more

Angewandte Chemie International Edition > 61 > 16 > n/a - n/a

The Stille cross‐coupling polymerization is one of the most efficient synthetic methods for donor–acceptor (D–A) type π‐conjugated polymers (CPs). Nevertheless, thermal‐activation Stille polymerization readily produced homocoupling defects, resulting in batch‐to‐batch variations in copolymers quality and deteriorating the device performance of electronics and optoelectronics. Here, a room‐temperature...

article

Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization

Bowei Ma, Qinqin Shi, Xiaoying Ma, Yawen Li, more

Angewandte Chemie > 134 > 16 > n/a - n/a

article

Ultrasound‐guided percutaneous transluminal angioplasty for the treatment of cephalic arch stenosis in hemodialysis arteriovenous fistulas

Xue Xing, Zhixiang Wang, Yi Yang, Jin Li, more

Seminars in Dialysis > 35 > 1 > 81 - 85

Objectives Cephalic arch stenosis (CAS) is a common cause that leads to the failure of hemodialysis arteriovenous fistulas (AVFs). Patients with CAS are primarily treated with fluoroscopy‐guided angioplasty. Here, seven patients with de novo cephalic arch stenosis who underwent office‐based UG‐PTA were. Methods Retrospectively analyzed the total of 321 patients with AVF dysfunction in the nephrology...

article

Rosamultin from Potentilla anserine L. exhibits nephroprotection and antioxidant activity by regulating the reactive oxygen species/C/EBP homologous protein signaling pathway

Luan He, Ning Liu, Kexin Wang, Ling Zhang, more

Phytotherapy Research > 35 > 11 > 6343 - 6358

Rosamultin, a major bioactive constituent from Potentilla anserine L., has antioxidative and hepatoprotective activities. However, its protective effects on cisplatin‐induced acute renal injury and the underlying mechanisms remain elusive. In this work, rosamultin could enhance the viability of HEK293 cells treated by cisplatin. In vivo experiment showed that rosamultin effectively decreased kidney...

article

Upfront transplantation may have better outcomes than pretransplant cytoreductive therapy for treating patients with MDS‐EB‐1 or MDS‐EB‐2

Yili Chen, Fen Huang, Li Xuan, Yu Zhang, more

International Journal of Cancer > 149 > 5 > 1109 - 1120

Whether patients with myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT) benefit from pretransplant cytoreductive therapy remains controversial. Our study compared the outcomes of upfront transplantation with those of pretransplant cytoreductive therapy in the patients who received transplantation and those who dropped out due to cytoreductive...

article

P‐233: Late‐News‐Poster: Color Shift Improvement of AMOLED Device with Color Filter

Xuan Zhao, Jinlei Huang, Zhixiang Wang, Insun Hwang

SID Symposium Digest of Technical Papers > 51 > 1 > 2111 - 2112

RGB CF structure having different thicknesses is introduced on the TFE, instead of a polarizer, to reduce the total thickness of the flexible display. Through optical simulation, we choose the appropriate RGB CF thicknesses and demonstrate CF array working with optical cavity could effectively improve the color shift with different view angles.

article

Towards deep‐blue phosphorescence: molecular design and property prediction of iridium complexes with pyridinylphosphinate ancillary ligand

Chongping Song, Jiaqi Li, Zhixiang Wang, Yanan Chen, more

Applied Organometallic Chemistry > 33 > 11 > n/a - n/a

A series of iridium complexes (1–5), which consist of two 2‐(2,4‐difluorophenyl)pyridine (dfppy)‐based primary ligands and one pyridinylphosphinate ancillary ligand, have been investigated theoretically for screening highly efficient deep‐blue light‐emitting materials. Compared with the reported dfppy‐based emitter 1, the designed iridium complexes 3–5 with the introduction of a stronger electron‐withdrawing...

article

Micronization of Gefitinib Using Solution‐Enhanced Dispersion by Supercritical CO₂

Jing Zhang, Qiming Wang, Zhonglin Zhu, Hongliang Qian, more

Chemical Engineering & Technology > 42 > 2 > 388 - 396

The antineoplastic gefitinib has a low aqueous solubility, leading to poor absorption rates. To overcome this problem, microparticles (MP) were prepared using solution‐enhanced dispersion by supercritical fluids (SEDS) with supercritical CO₂ and the cosolvents dichloromethane and ethanol. The results showed that the use of SEDS resulted in the formation of smaller particles and rendered the usually...

article

Parameterization of aerosol number concentration distributions from aircraft measurements in the lower troposphere over Northern China

Huige Di, Jing Zhao, Xuan Zhao, Yuxing Zhang, more

Journal of Quantitative Spectroscopy and Radiative Transfer > 2018 > 218 > C > 46-53

To obtain representative models of aerosol size distributions in the vertical dimension, we performed an extensive investigation on aerosol number concentration distributions from 0.1 µm to 3.0 µm based on airborne aerosol measurements, which were measured by a PCASP-100X on 33 flights over Northern China. A multi-modal lognormal size distribution with a base 10 logarithm is applied to fit the measured...

article

Polyethylenimine-coated iron oxide magnetic nanoparticles for high efficient gene delivery

Anh H. Nguyen, Gaser N. Abdelrasoul, Donghai Lin, Hamid Maadi, more

Applied Nanoscience > 2018 > 8 > 4 > 811-821

Properties of magnetic nanoparticles (MNPs) are of notable interest in many fields of biomedical engineering, especially for gene therapy. In this paper, we report a method for synthesis and delivery of MNPs loaded with DNAs, which overcomes the drawbacks of high cost and cytotoxicity associated with current delivery techniques (chemical- and liposome-based designs). 24-nm MNPs (Fe₃O₄) were synthesized,...

article

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2

Hamid Maadi, Babak Nami, Junfeng Tong, Gina Li, more

BMC Cancer > 2018 > 18 > 1 > 1-14

Background Targeted therapy with trastuzumab has become a mainstay for HER2-positive breast cancer without a clear understanding of the mechanism of its action. While many mechanisms have been suggested for the action of trastuzumab, most of them are not substantiated by experimental data. It has been suggested that trastuzumab functions by inhibiting intracellular signaling initiated by HER2, however,...

article

Preparation and characterization of naringenin microparticles via a supercritical anti-Solvent process

Honggang Miao, Zhen Chen, Wenbo Xu, Weiyan Wang, more

The Journal of Supercritical Fluids > 2018 > 131 > C > 19-25

Naringenin (NAR) exhibits many biological and pharmacological activities. However, its poor water-solubility and dissolution rate restrict its oral-intestinal absorption rate and bioavailability. In order to improve its dissolution rate, micronized NAR was successfully prepared using a supercritical anti-solvent process. A mixed acetone/dichloromethane solution and CO₂ were used as the solvent and...

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INFONA - science communication portal

Search results for: Zhixiang Wang

STAT5 phosphorylation plus minimal residual disease defines a novel risk classification in adult B‐cell acute lymphoblastic leukaemia

Adoptive therapy with cytomegalovirus‐specific cytotoxic T lymphocytes for refractory cytomegalovirus DNAemia and disease after allogeneic haematopoietic stem cell transplantation

Real‐time auto‐segmentation of the ureter in video sequences of gynaecological laparoscopic surgery

Idarubicin plus BuCy versus BuCy conditioning regimens for intermediate‐risk acute myeloid leukemia in first complete remission undergoing auto‐HSCT: An open‐label, multicenter, randomized phase 3 trial

A phase 2 study of sorafenib combined with conventional therapies in refractory central nervous system leukemia

Cidofovir, a choice for salvage treatment of cytomegalovirus infection in patients with haploidentical hematopoietic stem cell transplantation

Back Cover: Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization (Angew. Chem. Int. Ed. 16/2022)

Rücktitelbild: Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization (Angew. Chem. 16/2022)

Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization

Defect‐Free Alternating Conjugated Polymers Enabled by Room‐ Temperature Stille Polymerization

Ultrasound‐guided percutaneous transluminal angioplasty for the treatment of cephalic arch stenosis in hemodialysis arteriovenous fistulas

Rosamultin from Potentilla anserine L. exhibits nephroprotection and antioxidant activity by regulating the reactive oxygen species/C/EBP homologous protein signaling pathway

Upfront transplantation may have better outcomes than pretransplant cytoreductive therapy for treating patients with MDS‐EB‐1 or MDS‐EB‐2

P‐233: Late‐News‐Poster: Color Shift Improvement of AMOLED Device with Color Filter

Towards deep‐blue phosphorescence: molecular design and property prediction of iridium complexes with pyridinylphosphinate ancillary ligand

Micronization of Gefitinib Using Solution‐Enhanced Dispersion by Supercritical CO₂

Parameterization of aerosol number concentration distributions from aircraft measurements in the lower troposphere over Northern China

Polyethylenimine-coated iron oxide magnetic nanoparticles for high efficient gene delivery

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2

Preparation and characterization of naringenin microparticles via a supercritical anti-Solvent process

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