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eQTL mapping is to find loci on human genome that have demonstrated linkage to or association with the expression of a gene in microarray hybridization experiments. Such identified loci may contain important information on the regulatory factors of the given gene under study. In this talk, I will discuss co-regulation and inter-regulation patterns identified via similar strategies.
The genetical genomics approach has been used to study the genetic basis of variation in gene expression, where putative transcriptional regulators of genes are identified via genetic quantitative trait mapping. The genetic regulators identified through such efforts can partially account for an individual gene's natural variation. However, genes in a molecular pathway often exhibit coordinated activities,...
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