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A novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized by the condensation of 4-amino-5-[2-(4-chlorophenoxymethylbenzimidazole)-1-methylene]-3-mercapto-1,2,4-triazole with various (un)substituted aromatic acids in the presence of phosphorous oxychloride. These compounds were investigated for their inhibitory activity to E. coli methionine aminopeptidase (EcMetAP1)...
A facile one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazoles was achieved by ultrasonic irradiation of a mixture of 1-naphthylacetyl chloride, NH 4 CNS, CH 2 Cl 2 and PEG-400 for 1.5h at 10–20°C and subsequent irradiation for 1.5h in the presence of N-arylglycine hydrazides. This method requires short time and gives thiadiazoles in high yields.
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