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Background
The antimicrobial peptide (AMP) RNase 7 is constitutively expressed in the epidermis of healthy human skin and has been found to be upregulated in chronic inflammatory skin diseases such as atopic dermatitis and psoriasis. Activated T cells in lesional skin of patients with atopic dermatitis (AD) and psoriasis (PSO) might be directly exposed to RNase 7. In addition to their antimicrobial...
Background A number of studies have challenged the T‐cell‐centred pathogenetic view of psoriasis by the finding that epithelium‐expressed genes are intimately involved in the inflammatory process. Interleukin (IL)‐17 is an important inflammatory mediator in skin psoriasis.
Objective IL‐17 is known to act on keratinocytes and we were interested in its impact on the expression of pro‐ and anti‐inflammatory...
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