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Cancer cells exhibit enhanced lactate production to satisfy biosynthetic adenosine triphosphate requirements and also supply ribose 5‐phosphate (R5P) and nicotinamide adenine dinucleotide phosphate via the pentose phosphate pathway (PPP). Yet, little is known about the mechanism by which glycolytic flux is diverted to PPP to fulfill the increased demand for anabolic precursors and reducing equivalents...
A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (human plasma-like medium [HPLM]). Culture in HPLM, relative to that in traditional media, had widespread...
It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. Here, we analyzed metabolic gene expression in cancer cell lines and found that a set of high-grade carcinoma lines expressing mesenchymal markers share a unique 44 gene signature, designated...
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