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PurposeMyocardial fibrosis contributes to cardiac remodeling and loss of cardiac function in myocardial infarction and heart failure. This study used in vitro and in vivo models to examine the effects of ursolic acid (UA) on myocardial fibrosis and to explore its potential mechanism.
MethodsTransverse aortic constriction (TAC) surgery was performed in mice to induce cardiac hypertrophy and fibrosis...
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