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Aspasomes of methotrexate with antioxidant, ascorbyl palmitate, were developed and optimized using factorial design by varying parameters such as lipid molar ratio, drug to lipid molar ratio, and type of hydration buffer for transdermal delivery for disease modifying activity in rheumatoid arthritis (RA). Aspasomes were characterized by drug-excipients interaction, particle size analysis, determination...
Motor proteins are essential components of intracellular transport inside eukaryotic cells. These protein molecules use chemical energy obtained from hydrolysis of ATP to produce mechanical forces required for transporting cargos inside cells, from one location to another, in a directed manner. Of these motors, cytoplasmic dynein is structurally more complex than other motor proteins involved in intracellular...
The output voltage transient of a buck regulator during a load current step is often a key performance specification. However, many practical design approaches are based on frequency domain specifications like bandwidth and phase margin, without explicitly considering the constraints of the output filter. This paper derives an analytical expression for the peak transient output voltage due to a load...
Stringent output voltage regulation with faster transient response is demanded for dc-dc converters. A boost converter is important in LED lighting, photovoltaic systems, hybrid electric vehicles etc. But the presence of a Right Half Plane (RHP) zero in the small-signal model of a boost converter for its continuous current mode operation restricts its speed of response. With standard fixed frequency...
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