Search results for: Paaladinesh Thavendiranathan

Items from 1 to 20 out of 84 results

article

Magnetic Resonance Imaging of Cardiovascular Manifestations Following COVID‐19

Felipe Sanchez Tijmes, Constantin Marschner, Paaladinesh Thavendiranathan, Kate Hanneman

Journal of Magnetic Resonance Imaging > 58 > 1 > 26 - 43

Globally, over 650 million people have had COVID‐19 due to infection with the SARS‐Cov‐2 virus. Cardiac complications in the acute infectious and early recovery phase were recognized early in the pandemic, including myocardial injury and inflammation. With a decrease in the number of acute COVID‐19 related deaths, there has been increased interest in postacute sequela of COVID‐19 (PASC) and other...

article

Editorial for “Cardiac Magnetic Resonance Imaging Findings in COVID‐19 Vaccine‐Related Myocarditis: A Pooled Analysis of 468 Patients”

Kate Hanneman, Paaladinesh Thavendiranathan

Journal of Magnetic Resonance Imaging > 57 > 4 > 1289 - 1290

article

Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio‐Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio‐Oncology Society

Alexander R. Lyon, Susan Dent, Susannah Stanway, Helena Earl, more

European Journal of Heart Failure > 22 > 11 > 1945 - 1960

This position statement from the Heart Failure Association of the European Society of Cardiology Cardio‐Oncology Study Group in collaboration with the International Cardio‐Oncology Society presents practical, easy‐to‐use and evidence‐based risk stratification tools for oncologists, haemato‐oncologists and cardiologists to use in their clinical practice to risk stratify oncology patients prior to receiving...

article

The Role of Echocardiography in Cardio-oncology Patients: Contemporary Indications and Future Directions

Saiuj Bhat, Nestor Gahungu, Paaladinesh Thavendiranathan, Girish Dwivedi

Current Cardiovascular Imaging Reports > 2019 > 12 > 12 > 1-14

Purpose of Review This review discusses the latest advances, guideline recommendations, and limitations of the use of echocardiography in evaluation of cancer therapeutics–related cardiac dysfunction (CTRCD) and highlights advances in cardio-oncology that have the potential to augment the echocardiographic assessment of CTRCD. Recent Findings Cardio-oncology is a rapidly evolving field aimed at...

article

Cardiotoxicity of Immune Checkpoint Inhibitors

Lili Zhang, Maeve Jones-O’Connor, Magid Awadalla, Daniel A. Zlotoff, more

Current Treatment Options in Cardiovascular Medicine > 2019 > 21 > 7 > 1-17

Purpose of review Immunotherapies, particularly immune checkpoint inhibitors (ICI), are revolutionary cancer therapies being increasingly applied to a broader range of cancers. Our understanding of the mechanism, epidemiology, diagnosis, and treatment of cardiotoxicity related to immunotherapies remains limited. We aim to synthesize the limited current literature on cardiotoxicity of ICIs and to share...

article

Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors

Magid Awadalla, Doll Lauren Alexandra Golden, Syed S. Mahmood, Raza M. Alvi, more

Journal for ImmunoTherapy of Cancer > 2019 > 7 > 1 > 1-10

Background Influenza vaccination (FV) is recommended for patients with cancer. Recent data suggested that the administration of the FV was associated with an increase in immune-related adverse events (irAEs) among patients on immune checkpoint inhibitors (ICIs). Myocarditis is an uncommon but serious complication of ICIs and may also result from infection with influenza. There are no data testing...

article

Quantification of myocardial deformation by deformable registration–based analysis of cine MRI: validation with tagged CMR

Mariana M. Lamacie, Christian P. Houbois, Andreas Greiser, Marie-Pierre Jolly, more

European Radiology > 2019 > 29 > 7 > 3658-3668

Objectives To validate deformable registration algorithms (DRAs) for cine balanced steady-state free precession (bSSFP) assessment of global longitudinal strain (GLS) and global circumferential strain (GCS) using harmonic phase (HARP) cardiovascular magnetic resonance as standard of reference (SoR). Methods Seventeen patients and 17 volunteers underwent short axis stack and 2-/4-chamber cine bSSFP...

article

Cardioprotective Effect of Statins in Patients With HER2-Positive Breast Cancer Receiving Trastuzumab Therapy

Oscar Calvillo-Argüelles, Husam Abdel-Qadir, Maria Michalowska, Filio Billia, more

Canadian Journal of Cardiology > 2019 > 35 > 2 > 153-159

Statins can reduce the risk of anthracycline-induced cardiotoxicity. Whether such cardioprotective effects can be seen in trastuzumab-treated patients has not been explored.Consecutive women with HER2+ breast cancer who received trastuzumab with or without anthracyclines were identified retrospectively. Patients receiving statins before and during cancer treatment were matched with 2 patients of the...

article

Early diastolic strain rate measurements by cardiac MRI in breast cancer patients treated with trastuzumab: a longitudinal study

Inna Y. Gong, Geraldine Ong, Christine Brezden-Masley, Vinita Dhir, more

The International Journal of Cardiovascular Imaging > 2019 > 35 > 4 > 653-662

We evaluated temporal changes in early diastolic strain rates by cardiovascular magnetic resonance (CMR) as an early detector of trastuzumab-induced ventricular dysfunction. We conducted a prospective, multi-centre, longitudinal observational study of 41 trastuzumab-treated breast cancer women who underwent serial CMR (baseline, 6, 12, and 18 months). Two blinded readers independently measured left...

article

Single Versus Standard Multiview Assessment of Global Longitudinal Strain for the Diagnosis of Cardiotoxicity During Cancer Therapy

Paaladinesh Thavendiranathan, Tomoko Negishi, Marc-Andre Coté, Martin Penicka, more

JACC: Cardiovascular Imaging > 2018 > 11 > 8 > 1109-1118

The goal of this study was to compare echocardiographic measurements of global longitudinal strain (GLS) (using 3 apical views) with single-view longitudinal strain (LS, 4- or 2-chamber [4CV_LS and 2CV_LS, respectively]) for detection of cancer-therapy related cardiotoxicity.GLS is useful for the detection of cardiotoxicity, but the need for repeated measurements poses a significant burden on busy...

article

Rationale and Design of the Strain Surveillance of Chemotherapy for Improving Cardiovascular Outcomes

Tomoko Negishi, Paaladinesh Thavendiranathan, Kazuaki Negishi, Thomas H. Marwick, more

JACC: Cardiovascular Imaging > 2018 > 11 > 8 > 1098-1105

This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care.The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms and/or...

article

Do We Need Independent Data Monitoring Boards and Adaptive Designs for Papers About Methodology of Strain Measurement?

Thomas H. Marwick, Paaladinesh Thavendiranathan, Tomoko Negishi, Kazuaki Negishi

JACC: Cardiovascular Imaging > 2018 > 11 > 8 > 1207-1208

article

Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient

Juan Carlos Plana, Paaladinesh Thavendiranathan, Chiara Bucciarelli-Ducci, Patrizio Lancellotti

JACC: Cardiovascular Imaging > 2018 > 11 > 8 > 1173-1186

Cancer therapy can be associated with both cardiac and vascular toxicity. Advanced multi-modality imaging can be used to stratify patient risk, identify cardiovascular injury during and after therapy, and forecast recovery. Echocardiography continues to be the mainstay in the evaluation of cardiac toxicity. Particularly, echocardiography-based strain imaging is useful for risk stratification of patients...

article

Contemporary Role of Echocardiography for Clinical Decision Making in Patients During and After Cancer Therapy

Jennifer Liu, Jose Banchs, Negareh Mousavi, Juan Carlos Plana, more

JACC: Cardiovascular Imaging > 2018 > 11 > 8 > 1122-1131

Early recognition of cancer therapy–related cardiac dysfunction (CTRCD) provides an opportunity to mitigate cardiac injury and risk of developing late cardiac events. Echocardiography serves as the cornerstone in the detection and surveillance of CTRCD in patients during and after cancer therapy. Guidelines from professional societies and regulatory agencies have been published on approaches to surveillance,...

article

Is There Added Value of the Third Imaging Dimension in Cardio-Oncology?∗

Paaladinesh Thavendiranathan

JACC: Cardiovascular Imaging > 2018 > 11 > 8 > 1069-1071

article

Noninvasive hematocrit assessment for cardiovascular magnetic resonance extracellular volume quantification using a point-of-care device and synthetic derivation

Sean Robison, Gauri Rani Karur, Rachel M. Wald, Paaladinesh Thavendiranathan, more

Journal of Cardiovascular Magnetic Resonance > 2018 > 20 > 1 > 1-9

Background Calculation of cardiovascular magnetic resonance (CMR) extracellular volume (ECV) requires input of hematocrit, which may not be readily available. The purpose of this study was to evaluate the diagnostic accuracy of ECV calculated using various noninvasive measures of hematocrit compared to ECV calculated with input of laboratory hematocrit as the reference standard. Methods One hundred...

article

Remarks on the Position Paper on Cardio-Onco-Hematology and Remarks on the Review of Cardiac Imaging Modalities for the Detection of Cardiotoxicity. Response

Teresa López-Fernández, Paaladinesh Thavendiranathan, José Luis López-Sendón, Juan Carlos Plana Gómez

Revista Espa�ola de Cardiolog�a (English Edition) > 2017 > 70 > 11 > 1029-1030

article

Improving the Appropriate Use of Transthoracic Echocardiography

R. Sacha Bhatia, Noah M. Ivers, X. Cindy Yin, Dorothy Myers, more

Journal of the American College of Cardiology > 2017 > 70 > 9 > 1135-1144

Appropriate use criteria (AUC) have defined transthoracic echocardiogram (TTE) indications for which there is a clear lack of benefit as rarely appropriate (rA).This study sought to investigate the impact of an AUC-based educational intervention on outpatient TTE ordering by cardiologists and primary care providers.The authors conducted a prospective, investigator-blinded, multicenter, randomized...

article

Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics

Lynne K. Williams, Julian F. Forero, Zoran B. Popovic, Dermot Phelan, more

Journal of Cardiovascular Magnetic Resonance > 2017 > 19 > 1 > 1-10

Background Regional variability of longitudinal strain (LS) has been previously described with echocardiography in patients with cardiac amyloidosis (CA), however, the reason for this variability is not completely evident. We sought to describe regional patterns in LS using feature-tracking software applied to cardiovascular magnetic resonance (CMR) cine images in patients with CA, hypertrophic cardiomyopathy...

article

Left Atrial Phasic Function and Its Association With Atrial Fibrillation in Patients After Transcatheter Aortic Valve Implantation

Frédéric Poulin, Paaladinesh Thavendiranathan, Shemy Carasso, Harry Rakowski, more

Canadian Journal of Cardiology > 2017 > 33 > 7 > 925-932

Left atrial (LA) size is a marker of prognosis in severe aortic stenosis (AS). The aims of this retrospective study were to assess the impact of transcatheter aortic valve implantation (TAVI) on the recovery of LA phasic function and to assess the relationship between LA function and new-onset atrial fibrillation (NAF) after TAVI.In this retrospective cohort study, LA function was measured using biplane...

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INFONA - science communication portal

Search results for: Paaladinesh Thavendiranathan

Magnetic Resonance Imaging of Cardiovascular Manifestations Following COVID‐19

Editorial for “Cardiac Magnetic Resonance Imaging Findings in COVID‐19 Vaccine‐Related Myocarditis: A Pooled Analysis of 468 Patients”

The Role of Echocardiography in Cardio-oncology Patients: Contemporary Indications and Future Directions

Cardiotoxicity of Immune Checkpoint Inhibitors

Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors

Quantification of myocardial deformation by deformable registration–based analysis of cine MRI: validation with tagged CMR

Cardioprotective Effect of Statins in Patients With HER2-Positive Breast Cancer Receiving Trastuzumab Therapy

Early diastolic strain rate measurements by cardiac MRI in breast cancer patients treated with trastuzumab: a longitudinal study

Single Versus Standard Multiview Assessment of Global Longitudinal Strain for the Diagnosis of Cardiotoxicity During Cancer Therapy

Rationale and Design of the Strain Surveillance of Chemotherapy for Improving Cardiovascular Outcomes

Do We Need Independent Data Monitoring Boards and Adaptive Designs for Papers About Methodology of Strain Measurement?

Multi-Modality Imaging in the Assessment of Cardiovascular Toxicity in the Cancer Patient

Contemporary Role of Echocardiography for Clinical Decision Making in Patients During and After Cancer Therapy

Is There Added Value of the Third Imaging Dimension in Cardio-Oncology?∗

Noninvasive hematocrit assessment for cardiovascular magnetic resonance extracellular volume quantification using a point-of-care device and synthetic derivation

Remarks on the Position Paper on Cardio-Onco-Hematology and Remarks on the Review of Cardiac Imaging Modalities for the Detection of Cardiotoxicity. Response

Improving the Appropriate Use of Transthoracic Echocardiography

Patterns of CMR measured longitudinal strain and its association with late gadolinium enhancement in patients with cardiac amyloidosis and its mimics

Left Atrial Phasic Function and Its Association With Atrial Fibrillation in Patients After Transcatheter Aortic Valve Implantation

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