Search results for: Lisa G. Wood

Items from 1 to 20 out of 45 results

article

Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts

Stephany Sánchez‐Ovando, Stelios Pavlidis, Nazanin Zounemat Kermani, Katherine Joanne Baines, more

Background and objective Severe asthma (SA) is a heterogeneous disease. Transcriptomic analysis contributes to the understanding of pathogenesis necessary for developing new therapies. We sought to identify and validate mechanistic pathways of SA across two independent cohorts. Methods Transcriptomic profiles from U‐BIOPRED and Australian NOVocastrian Asthma cohorts were examined and grouped into...

article

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype

Michael Fricker, Ling Qin, Stephany Sánchez‐Ovando, Jodie L. Simpson, more

Allergy > 77 > 4 > 1204 - 1215

Background Neutrophilic asthma (NA) is a clinically important asthma phenotype, the cellular and molecular basis of which is not completely understood. Airway macrophages are long‐lived immune cells that exert important homeostatic and inflammatory functions which are dysregulated in asthma. Unique transcriptomic programmes reflect varied macrophage phenotypes in vitro. We aimed to determine whether...

article

Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

Li Huang, Sen‐Te Wang, Han‐Pin Kuo, Christophe Delclaux, more

Obesity Reviews > 22 > 12 > n/a - n/a

Adults with obesity exhibit a restrictive pattern, whereas children with obesity exhibit an obstructive pattern. However, the transition process remains unclear. We performed a systematic search for studies reporting on body mass index and pulmonary function in children. The main outcomes were forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC), and their ratio (FEV₁/FVC). We compared...

article

The effects of increasing fruit and vegetable intake in children with asthma: A randomized controlled trial

Bronwyn S. Berthon, Rebecca F. McLoughlin, Megan E. Jensen, Banafshe Hosseini, more

Clinical & Experimental Allergy > 51 > 9 > 1144 - 1156

Background A high fruit and vegetable (F&V) diet reduces asthma exacerbations in adults; this has not been examined in children to date. Objective To investigate the effect of a 6‐month, high F&V diet on the time to first asthma exacerbation in children with asthma, in a parallel‐group, randomized, controlled trial. Methods Children (aged 3–11 years) with asthma, history of exacerbations...

article

We can do better in COPD: Time for action to preserve body composition

Lisa G. Wood

Respirology > 26 > 9 > 828 - 829

See related article

article

Diet and lung disease—Are fruits and vegetables the ideal whole‐food intervention?

Lisa G. Wood

Respirology > 26 > 6 > 527 - 528

article

Sputum transcriptomics implicates increased p38 signalling activity in severe asthma

Katherine J. Baines, Michael Fricker, Vanessa M. McDonald, Jodie L. Simpson, more

Respirology > 25 > 7 > 709 - 718

Background and objective Severe asthma is responsible for a disproportionate burden of illness and healthcare costs spent on asthma. This study analyses sputum transcriptomics to investigate the mechanisms and novel treatment targets of severe asthma. Methods Induced sputum samples were collected in a cross‐sectional study from participants with severe asthma (n = 12, defined as per GINA criteria),...

article

Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes

Ling Qin, Peter G. Gibson, Jodie L. Simpson, Katherine J. Baines, more

Clinical & Experimental Allergy > 49 > 11 > 1418 - 1428

Background Dysfunction of the bronchial epithelium plays an important role in asthma; however, its measurement is challenging. Columnar epithelial cells are often quantified, yet rarely analysed, in induced sputum studies. Objective We aimed to test whether sputum columnar epithelial cell proportion and count are altered in asthma, and whether they are associated with clinical and inflammatory...

article

Carotenoids, fatty acids and disease burden in obese minority adolescents with asthma

Toni A. M. Tobias, Lisa G. Wood, Deepa Rastogi

Clinical & Experimental Allergy > 49 > 6 > 838 - 846

Background Paediatric obesity‐related asthma causes high disease burden, is associated with metabolic abnormalities, has few therapeutic options, and disproportionately affects urban minority children. Although poor diet quality is linked to asthma, the association of nutritional status with disease burden among children with obesity‐related asthma is not well understood. Objective To quantify...

article

Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD

Sandra Rutting, Michael Papanicolaou, Dia Xenaki, Lisa G. Wood, more

Respiratory Research > 2018 > 19 > 1 > 1-12

Background The obesity paradox in COPD describes protective effects of obesity on lung pathology and inflammation. However, the underlying relationships between obesity, diet and disease outcomes in COPD are not fully understood. In this study we measured the response to dietary fatty acids upon markers of inflammation and remodelling in human lung cells from people with and without COPD. Methods...

article

Is the consumption of fast foods associated with asthma or other allergic diseases?

Cheng S. Wang, Ji Wang, Xin Zhang, Li Zhang, more

Respirology > 23 > 10 > 901 - 913

The associations between the consumption of fast foods and asthma or allergic diseases have not been clarified. The aim of this study was to determine whether fast foods consumption is associated with asthma or allergic diseases. Databases were searched up to February 2018. Studies investigating the associations between fast foods consumption and asthma or allergic diseases were considered eligible...

article

Fish oil supplementation in chronic obstructive pulmonary disease: feasibility of conducting a randomised controlled trial

Ashley S. Fulton, Alison M. Coates, Marie T Williams, Peter R. C. Howe, more

Pilot and Feasibility Studies > 2017 > 3 > 1 > 1-9

Background Long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFAs) may act as an effective adjunct therapy for chronic obstructive pulmonary disease (COPD), a condition characterised by persistent airflow limitation and inflammation. However, the nature of this illness presents challenges for evaluating potential benefits. The aim of this study was to determine the feasibility of undertaking a...

article

Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness

Cintia Botelho Dias, Paul J. Moughan, Lisa G. Wood, Harjinder Singh, more

Lipids in Health and Disease > 2017 > 16 > 1 > 1-11

One of the limitations for ranking foods and meals for healthiness on the basis of the glycaemic index (GI) is that the GI is subject to manipulation by addition of fat. Postprandial lipemia, defined as a rise in circulating triglyceride containing lipoproteins following consumption of a meal, has been recognised as a risk factor for the development of cardiovascular disease and other chronic diseases...

article

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma

Philip M. Hansbro, Richard Y. Kim, Malcolm R. Starkey, Chantal Donovan, more

Immunological Reviews > 278 > 1 > 41 - 62

Severe, steroid‐resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with this disease experience more frequent exacerbations of asthma, are more likely to be hospitalized, and have a poorer quality of life. Effective therapies are urgently required, however, their development has been hampered...

article

Role of Obesity in Asthma: Mechanisms and Management Strategies

Hayley A Scott, Lisa G Wood, Peter G Gibson

Current Allergy and Asthma Reports > 2017 > 17 > 8 > 1-10

Purpose of Review Obesity is a commonly reported comorbidity in asthma, particularly in severe asthma. Obese asthmatics are highly symptomatic with a poor quality of life, despite using high-dose inhaled corticosteroids. While the clinical manifestations have been documented, the aetiologies of obese-asthma remain unclear. Recent Findings Several potential mechanisms have been proposed, including...

article

Inflammasomes in the lung

James W. Pinkerton, Richard Y. Kim, Avril A.B. Robertson, Jeremy A. Hirota, more

Molecular Immunology > 2017 > 86 > C > 44-55

Innate immune responses act as first line defences upon exposure to potentially noxious stimuli. The innate immune system has evolved numerous intracellular and extracellular receptors that undertake surveillance for potentially damaging particulates. Inflammasomes are intracellular innate immune multiprotein complexes that form and are activated following interaction with these stimuli. Inflammasome...

article

Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles

Cintia B. Dias, Núria Amigó, Lisa G. Wood, Roger Mallol, more

Metabolism > 2017 > 68 > C > 11-19

Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated.In a randomized controlled parallel design clinical...

article

Consuming High-Carotenoid Fruit and Vegetables Influences Skin Yellowness and Plasma Carotenoids in Young Women: A Single-Blind Randomized Crossover Trial

Kristine Pezdirc, Melinda J. Hutchesson, Rebecca L. Williams, Megan E. Rollo, more

Journal of the Academy of Nutrition and Dietetics > 2016 > 116 > 8 > 1257-1265

Consumption of dietary carotenoids from fruits and vegetables (F/V) leads to accumulations in human skin, altering skin yellowness. The influence of the quantity of F/V consumed on skin yellowness and plasma carotenoid concentrations has not been examined previously.To compare the influence of consuming high-carotenoid-containing F/V (HCFV) (176,425 μg beta carotene/wk) vs low-carotenoid F/V (LCFV)...

article

Should we treat obesity in COPD? The effects of diet and resistance exercise training

Vanessa M. McDonald, Peter G. Gibson, Hayley A. Scott, Penelope J. Baines, more

Respirology > 21 > 5 > 875 - 882

Background and objectiveObesity is an established risk factor for poor health outcomes, but paradoxically in chronic obstructive pulmonary disease (COPD), it is associated with improved survival and lung function. A major evidence gap exisits to inform treatment recommendations for patients with COPD who are obese. We aimed to determine the effect of weight reduction involving a low‐energy diet utilizing...

article

Energy homeostasis and appetite regulating hormones as predictors of weight loss in men and women

Rebecca L. Williams, Lisa G. Wood, Clare E. Collins, Philip J. Morgan, more

Appetite > 2016 > 101 > C > 1-7

Sex differences in weight loss are often seen despite using the same weight loss program. There has been relatively little investigation of physiological influences on weight loss success in males and females, such as energy homeostasis and appetite regulating hormones. The aims were to 1) characterise baseline plasma leptin, ghrelin and adiponectin concentrations in overweight and obese males and...

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INFONA - science communication portal

Search results for: Lisa G. Wood

Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype

Effects of obesity on pulmonary function considering the transition from obstructive to restrictive pattern from childhood to young adulthood

The effects of increasing fruit and vegetable intake in children with asthma: A randomized controlled trial

We can do better in COPD: Time for action to preserve body composition

Diet and lung disease—Are fruits and vegetables the ideal whole‐food intervention?

Sputum transcriptomics implicates increased p38 signalling activity in severe asthma

Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes

Carotenoids, fatty acids and disease burden in obese minority adolescents with asthma

Dietary ω-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD

Is the consumption of fast foods associated with asthma or other allergic diseases?

Fish oil supplementation in chronic obstructive pulmonary disease: feasibility of conducting a randomised controlled trial

Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma

Role of Obesity in Asthma: Mechanisms and Management Strategies

Inflammasomes in the lung

Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles

Consuming High-Carotenoid Fruit and Vegetables Influences Skin Yellowness and Plasma Carotenoids in Young Women: A Single-Blind Randomized Crossover Trial

Should we treat obesity in COPD? The effects of diet and resistance exercise training

Energy homeostasis and appetite regulating hormones as predictors of weight loss in men and women

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