Search results for: Donald F. Smith

Items from 1 to 20 out of 51 results

article

Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate

Benjamin L. Oyler, Mohd M. Khan, Donald F. Smith, Erin M. Harberts, more

Journal of The American Society for Mass Spectrometry > 2018 > 29 > 6 > 1230-1230

In the preceding article “Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate” by Oyler et al., an error in the J5 E. coli LPS chemical structure (Figs. 2 and 4) was introduced and propagated into the final revision.

article

Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate

Benjamin L. Oyler, Mohd M. Khan, Donald F. Smith, Erin M. Harberts, more

Journal of The American Society for Mass Spectrometry > 2018 > 29 > 6 > 1221-1229

Recent advances in lipopolysaccharide (LPS) biology have led to its use in drug discovery pipelines, including vaccine and vaccine adjuvant discovery. Desirable characteristics for LPS vaccine candidates include both the ability to produce a specific antibody titer in patients and a minimal host inflammatory response directed by the innate immune system. However, in-depth chemical characterization...

article

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Christopher L. Hendrickson, John P. Quinn, Nathan K. Kaiser, Donald F. Smith, more

Journal of The American Society for Mass Spectrometry > 2015 > 26 > 9 > 1626-1632

We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front...

article

Mass spectrometry imaging of biological tissue: an approach for multicenter studies

Andreas Römpp, Jean-Pierre Both, Alain Brunelle, Ron M. A. Heeren, more

Analytical and Bioanalytical Chemistry > 2015 > 407 > 8 > 2329-2335

Mass spectrometry imaging has become a popular tool for probing the chemical complexity of biological surfaces. This led to the development of a wide range of instrumentation and preparation protocols. It is thus desirable to evaluate and compare the data output from different methodologies and mass spectrometers. Here, we present an approach for the comparison of mass spectrometry imaging data from...

article

Distributed computing strategies for processing of FT-ICR MS imaging datasets for continuous mode data visualization

Donald F. Smith, Carl Schulz, Marco Konijnenburg, Mehmet Kilic, more

Analytical and Bioanalytical Chemistry > 2015 > 407 > 8 > 2321-2327

High-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging enables the spatial mapping and identification of biomolecules from complex surfaces. The need for long time-domain transients, and thus large raw file sizes, results in a large amount of raw data (“big data”) that must be processed efficiently and rapidly. This can be compounded by large-area imaging and/or...

article

Top‐down mass spectrometry imaging of intact proteins by laser ablation ESI FT‐ICR MS

András Kiss, Donald F. Smith, Brent R. Reschke, Matthew J. Powell, more

PROTEOMICS > 14 > 10 > 1283 - 1289

Laser ablation ESI (LAESI) is a recent development in MS imaging. It has been shown that lipids and small metabolites can be imaged in various samples such as plant material, tissue sections or bacterial colonies without any sample pretreatment. Further, LAESI has been shown to produce multiply charged protein ions from liquids or solid surfaces. This presents a means to address one of the biggest...

article

Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

Sarfaraz U. A. H. Syed, Gert B. Eijkel, Piet Kistemaker, Shane Ellis, more

Journal of The American Society for Mass Spectrometry > 2014 > 25 > 10 > 1780-1787

In this paper, we have employed an ion imaging approach to investigate the behavior of ions exiting from a quadrupole mass spectrometer (QMS) system that employs a radio frequency octopole ion guide before the QMS. An in-vacuum active pixel detector (Timepix) is employed at the exit of the QMS to image the ion patterns. The detector assembly simultaneously records the ion impact position and number...

article

Cluster secondary ion mass spectrometry microscope mode mass spectrometry imaging

András Kiss, Donald F. Smith, Julia H. Jungmann, Ron M. A. Heeren

Rapid Communications in Mass Spectrometry > 27 > 24 > 2745 - 2750

RATIONALEMicroscope mode imaging for secondary ion mass spectrometry is a technique with the promise of simultaneous high spatial resolution and high‐speed imaging of biomolecules from complex surfaces. Technological developments such as new position‐sensitive detectors, in combination with polyatomic primary ion sources, are required to exploit the full potential of microscope mode mass spectrometry...

article

Enhanced Detection of High‐Mass Proteins by Using an Active Pixel Detector

Shane R. Ellis, Julia H. Jungmann, Donald F. Smith, Jens Soltwisch, more

Angewandte Chemie > 125 > 43 > 11471 - 11474

Flugfähig: Ein aktiver Pixeldetektor mit hoher Ladungsempfindlichkeit wurde in einem Flugzeit‐Massenspektrometer eingesetzt, um Proteine mit großer Molekülmasse (z. B. Immunglobulin G; IgG) mithilfe eines herkömmlichen Mikrokanalplattendetektors besser nachzuweisen. Dadurch lässt sich der Massenbereich solcher Detektoren vergrößern, und es gelingt eine direkte Visualisierung masseabhängiger Ionenfokussier‐Phänomene...

article

Enhanced Detection of High‐Mass Proteins by Using an Active Pixel Detector

Shane R. Ellis, Julia H. Jungmann, Donald F. Smith, Jens Soltwisch, more

Angewandte Chemie International Edition > 52 > 43 > 11261 - 11264

Flying high: Application of an active pixel detector with high charge sensitivity to a linear time‐of‐flight mass spectrometer results in enhanced detection of high‐mass proteins (such as Immunoglobulin G; IgG) using a conventional microchannel plate detection system. This technique thus provides a means to extend the mass range of such detectors as well as allowing direct visualization of mass‐dependent...

article

An in-vacuum, pixelated detection system for mass spectrometric analysis and imaging of macromolecules

Julia H. Jungmann, Donald F. Smith, Andras Kiss, Luke MacAleese, more

International Journal of Mass Spectrometry > 2013 > 341-342 > Complete > 34-44

The analytical capabilities of a Timepix detection system for mass spectrometry (imaging) are extended by the application of additional acceleration fields. Electrically biasing the detection system at a high potential delivers effective ion acceleration energies of 15/11keV for positive/negative ion mode matrix-assisted laser desorption ionization. This is comparable to the acceleration/extraction...

article

Replication attempt to estimate depression severity by fuzzy logic analysis of emotion‐focused fMRI

Donald F. Smith, Hanne Nødskov, Michael Winterdahl, Torben E. Lund

Journal of Magnetic Resonance Imaging > 37 > 2 > 498 - 499

article

Benefits of flavanol-rich cocoa-derived products for mental well-being: A review

Donald F. Smith

Journal of Functional Foods > 2013 > 5 > 1 > 10-15

This review explores the possibility that central actions of flavanol-rich cocoa-derived products are of benefit in the prevention and treatment of mood disorders. Flavanol-rich cocao-derived products have been studied in both neuromolecular and psychological tests. Neuromolecular effects of flavanols in cocoa-derived products include antioxidant, vasodilatory, anticoagulant, and antiinflammatory...

article

A MASSive Laboratory Tour. An Interactive Mass Spectrometry Outreach Activity for Children

Julia H. Jungmann, Nadine E. Mascini, Andras Kiss, Donald F. Smith, more

Journal of The American Society for Mass Spectrometry > 2013 > 24 > 7 > 979-982

It is imperative to fascinate young children at an early stage in their education for the analytical sciences. The exposure of the public to mass spectrometry presently increases rapidly through the common media. Outreach activities can take advantage of this exposure and employ mass spectrometry as an exquisite example of an analytical science in which children can be fascinated. The presented teaching...

article

High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging

Donald F. Smith, Andras Kiss, Franklin E. Leach, Errol W. Robinson, more

Analytical and Bioanalytical Chemistry > 2013 > 405 > 18 > 6069-6076

Biological tissue imaging by secondary ion mass spectrometry has seen rapid development with the commercial availability of polyatomic primary ion sources. Endogenous lipids and other small bio-molecules can now be routinely mapped on the sub-micrometer scale. Such experiments are typically performed on time-of-flight mass spectrometers for high sensitivity and high repetition rate imaging. However,...

article

Advanced Mass Calibration and Visualization for FT-ICR Mass Spectrometry Imaging

Donald F. Smith, Andriy Kharchenko, Marco Konijnenburg, Ivo Klinkert, more

Journal of The American Society for Mass Spectrometry > 2012 > 23 > 11 > 1865-1872

Mass spectrometry imaging by Fourier transform ion cyclotron resonance (FT-ICR) yields hundreds of unique peaks, many of which cannot be resolved by lower performance mass spectrometers. The high mass accuracy and high mass resolving power allow confident identification of small molecules and lipids directly from biological tissue sections. Here, calibration strategies for FT-ICR MS imaging were investigated...

article

Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector

Julia H. Jungmann, Donald F. Smith, Luke MacAleese, Ivo Klinkert, more

Journal of The American Society for Mass Spectrometry > 2012 > 23 > 10 > 1679-1688

We demonstrate the capabilities of a highly parallel, active pixel detector for large-area, mass spectrometric imaging of biological tissue sections. A bare Timepix assembly (512 × 512 pixels) is combined with chevron microchannel plates on an ion microscope matrix-assisted laser desorption time-of-flight mass spectrometer (MALDI TOF-MS). The detector assembly registers position- and time-resolved...

article

C ₆₀ Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Donald F. Smith, Errol W. Robinson, Aleksey V. Tolmachev, Ron M. A. Heeren, more

Analytical Chemistry > 2011 > 83 > 24 > 9552 - 9556

article

Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the Göttingen minipig

Sandra Guidi, Patrizia Bianchi, Aage K. Olsen Alstrup, Kim Henningsen, more

Brain Research Bulletin > 2011 > 85 > 3-4 > 169-179

Postnatal neurogenesis is currently viewed as important for neuroplasticity and brain repair. We are, therefore, interested in animal models for neuroimaging of postnatal neurogenesis. A recent stereological study found an age-dependent increase in the number of neurons and glial cells in the neocortex of Göttingen minipigs, suggesting that this species may be characterized by a prolonged postnatal...

article

End-Group Analysis of Methacrylic (Co)polymers by LC-ESI-MS ²

Junkan Song, Jan W. van Velde, Luc L. T. Vertommen, Donald F. Smith, more

Macromolecules > 2011 > 44 > 6 > 1319 - 1326

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IMAGING MASS SPECTROMETRY (8)
PET (8)
ANTIDEPRESSANT (7)
MALDI (6)
BINDING POTENTIAL (4)
HUMAN BRAIN (4)
MIRTAZAPINE (4)
POSITRON EMISSION TOMOGRAPHY (4)
FTMS (3)
MASS SPECTROMETRY IMAGING (3)
PET NEUROIMAGING (3)
PHARMACOKINETICS (3)
PORCINE BRAIN (3)
SIMS (3)
ACTIVE PIXEL DETECTOR (2)
ANTIDEPRESSANT DRUG (2)
AUTORADIOGRAPHY (2)
BIODISTRIBUTION (2)
BRAIN IMAGING (2)
DEPRESSION (2)
FOURIER TRANSFORM (2)
FT-ICR (2)
HIGH RESOLUTION (2)
HUMAN (2)
MASS SPECTROMETRY (2)
MCP (2)
MOOD DISORDERS (2)
SPECT (2)
TIMEPIX (2)
[11C]MIRTAZAPINE (2)
6-[ 1 8 F]FLUORO-L-3,4-DIHYDROXYPHENYLALANINE (1)
CMRO 2 (1)
[ 1 1 C]MIRTAZAPINE (1)
[N-METHYL- 1 1 C]MIRTAZAPINE (1)
5-HT UPTAKE (1)
ACCURATE MASS (1)
ADC (1)
ADRENOCEPTORS (1)
ANTI-DEPRESSANT (1)
BIPOLAR DEPRESSION (1)
BLOOD PLATELETS (1)
BRAIN (1)
BRDU (1)
BUILDING BLOCKS OF MATTER (1)
C60 (1)
CBF (1)
CHARGED PARTICLE MANIPULATION (1)
CLOUD COMPUTING (1)
COLLISION INDUCED DISSOCIATION (1)
DARK CHOCOLATE (1)
DATA FORMAT IMZML (1)
DATA HANDLING AND PROCESSING (1)
DESI (1)
DISTRIBUTION VOLUME (1)
DOSIMETRY (1)
ENANTIOMER (1)
ENANTIOMERS (1)
EXERCISE (1)
FDOPA (1)
FLAVANOL (1)
FOURIER TRANSFORM MASS SPECTROMETRY (1)
FT-MS (1)
GERMINAL NICHES (1)
GIGABIT READ-OUT (1)
GRANULE CELLS (1)
HIGH DYNAMIC RANGE (1)
HIGH M/Z (1)
HIGH RESOLUTION MASS SPECTROMETRY (1)
HIGH SPATIAL RESOLUTION (1)
HIGH VOLTAGE (1)
HIGH‐MASS DETECTION (1)
HYPOTHERMIA (1)
IMAGING MS (1)
IMMUNOHISTOCHEMISTRY (1)
IN-VACUUM MOUNTING (1)
INCAS (1)
INTACT PROTEIN (1)
ION CYCLOTRON RESONANCE (1)
ION TRANSMISSION (1)
IONS (1)
KINETIC MODELS (1)
LIPID A (1)
LIPIDS (1)
LIPOPOLYSACCHARIDE (1)
MAJOR DEPRESSIVE DISORDER (1)
MAO (1)
MASSENSPEKTROMETRIE (1)
MICROCHANNEL PLATE (1)
MICROSCOPE MODE (1)
MIKROKANALPLATTEN (1)
MINIPIG (1)
MOLECULAR HISTOLOGY (1)
MULTICENTER STUDIES (1)
MULTIMODAL IMAGING (1)
MULTIPLEXED TDC (1)
NASSA (1)
NATURAL PRODUCTS (1)
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Springer (18)
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ACS (11)
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Journal of The American Society for Mass Spectrometry (10)
Energy & Fuels (6)
European Neuropsychopharmacology (5)
Psychopharmacology (4)
Analytical Chemistry (3)
Analytical and Bioanalytical Chemistry (3)
NeuroImage (2)
Rapid Communications in Mass Spectrometry (2)
Angewandte Chemie (1)
Angewandte Chemie International Edition (1)
Applied Radiation and Isotopes (1)
Biological Psychiatry (1)
Brain Research Bulletin (1)
EJNMMI Research (1)
Environmental Science & Technology (1)
International Congress Series (1)
International Journal of Mass Spectrometry (1)
Journal of Chromatography A (1)
Journal of Functional Foods (1)
Journal of Magnetic Resonance Imaging (1)
Journal of Neuroscience Methods (1)
Journal of the American Society for Mass Spectrometry (1)
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INFONA - science communication portal

Search results for: Donald F. Smith

Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate

Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Mass spectrometry imaging of biological tissue: an approach for multicenter studies

Distributed computing strategies for processing of FT-ICR MS imaging datasets for continuous mode data visualization

Top‐down mass spectrometry imaging of intact proteins by laser ablation ESI FT‐ICR MS

Experimental Investigation of the 2D Ion Beam Profile Generated by an ESI Octopole-QMS System

Cluster secondary ion mass spectrometry microscope mode mass spectrometry imaging

Enhanced Detection of High‐Mass Proteins by Using an Active Pixel Detector

Enhanced Detection of High‐Mass Proteins by Using an Active Pixel Detector

An in-vacuum, pixelated detection system for mass spectrometric analysis and imaging of macromolecules

Replication attempt to estimate depression severity by fuzzy logic analysis of emotion‐focused fMRI

Benefits of flavanol-rich cocoa-derived products for mental well-being: A review

A MASSive Laboratory Tour. An Interactive Mass Spectrometry Outreach Activity for Children

High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging

Advanced Mass Calibration and Visualization for FT-ICR Mass Spectrometry Imaging

Biological Tissue Imaging with a Position and Time Sensitive Pixelated Detector

C ₆₀ Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Postnatal neurogenesis in the hippocampal dentate gyrus and subventricular zone of the Göttingen minipig

End-Group Analysis of Methacrylic (Co)polymers by LC-ESI-MS ²

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