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Gene expression profiling from glioblastoma (GBM) patients enables characterization of cancer into subtypes that can be predictive of response to therapy. An integrative analysis of imaging and gene expression data can potentially be used to obtain novel biomarkers that are closely associated with the genetic subtype and gene signatures and thus provide a noninvasive approach to stratify GBM patients...
Routinely, compounds are assessed by developmental and reproductive toxicology (DART) studies to evaluate the potential for drug-induced birth defects. High-throughput micro-CT images are being used to evaluate skeletal abnormalities due to its ability to provide high quality images of bone structures. Currently, these micro-CT images are visually inspected for skeletal abnormalities, which is a time...
Odanacatib (ODN) is a selective and reversible Cathepsin K (CatK) inhibitor currently being developed as a once weekly treatment for osteoporosis. Here, effects of ODN compared to alendronate (ALN) on bone turnover, DXA-based areal bone mineral density (aBMD), QCT-based volumetric BMD (vBMD) and geometric parameters were studied in ovariectomized (OVX) rhesus monkeys. Treatment was initiated 10days...
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