Search results for: Tomasz Grabowski

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article

Północnokaukascy bojownicy w szeregach Państwa Islamskiego. Profil psychologiczno-społeczny oraz mechanizmy rekrutacji

Tomasz Grabowski

Przegląd Orientalistyczny > 2020 > 2-3 (274-275) "Świat islamu w perspektywie badań arabistycznych i politologicznych Historia i współczesność" > 145-164

The main aim of the article is to create a psychological profile of people from the North Caucasus who have voluntarily joined the Islamic State and fight in its ranks. In addition, it determines motives that govern these individuals and describes what mechanisms are used during volunteers’ recruitment. Threats to international security created by North Caucasian militants after the fall of the Islamic...

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PHARMACOKINETIC INTERACTION AFTER ORAL COADMINISTRATION OF CLARITHROMYCIN AND THE TYROSINE KINASE INHIBITOR LAPATINIB IN RATS

Agnieszka Karbownik, Joanna Porażka, Anna Łuczak, Artur Teżyk, more

Acta Poloniae Pharmaceutica - Drug Research > 2019 > 76 > 4 > 645-651

article

Fluctuations in Pharmacokinetics Profiles of Monoclonal Antibodies

Tomasz Grabowski, Joannes A. A. Reijers, Artur Burmańczuk, Anna Chełmońska-Soyta

European Journal of Drug Metabolism and Pharmacokinetics > 2019 > 44 > 5 > 585-589

Monoclonal antibodies (mAbs) are a group of drugs with predicted slow linear and target-mediated distribution and elimination. Visual inspection of published pharmacokinetic profiles of mAbs frequently reveals plateaus in the distribution phase or an increasing concentration many days after a single intravenous dose. A question which has been left unanswered until now is whether mAbs undergo recirculation...

article

Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration

Joanna Porażka, Edyta Szałek, Wojciech Połom, Mateusz Czajkowski, more

European Journal of Drug Metabolism and Pharmacokinetics > 2019 > 44 > 4 > 579-584

Background and Objectives The number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g., by altering the activity of cytochrome P450 (CYP) isoenzymes. Tramadol is a commonly used analgesic metabolised mainly via CYP2D6 to its active metabolite, O-desmethyltramadol. The aim of the study was to assess the influence...

article

The Influence of Diabetes Mellitus on Glucuronidation and Sulphation of Paracetamol in Patients with Febrile Neutropenia

Anna Stachowiak, Edyta Szałek, Agnieszka Karbownik, Anna Łojko, more

European Journal of Drug Metabolism and Pharmacokinetics > 2019 > 44 > 2 > 289-294

Background and Objectives Numerous studies have confirmed the influence of diabetes mellitus on the pharmacokinetics of drugs. Paracetamol (APAP) is an antipyretic that is commonly used in febrile neutropenia (FN) therapy. APAP is chiefly metabolised by glucuronidation and sulphation. This study assessed the influence of diabetes on the pharmacokinetics of paracetamol and its metabolites: glucuronide...

article

Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines

Jasbir Singh, Fawzy Elbarbry, Ke Lan, Tomasz Grabowski

European Journal of Drug Metabolism and Pharmacokinetics > 2018 > 43 > 5 > 483-494

Animal pharmacokinetic/pharmacodynamic studies are commonly used to provide meaningful preclinical information that can be utilized by the scientific community to conduct first-in-human studies. Poor presentation and interpretation of the data limit study reproducibility, and may result in rejection when the study is submitted to a journal, leading to loss of time and resources at multiple levels...

article

Quercetin decrease somatic cells count in mastitis of dairy cows

Artur Burmańczuk, Piotr Hola, Andrzej Milczak, Tomasz Piech, more

Research in Veterinary Science > 2018 > 117 > C > 255-259

Quercetin is a dietary flavonoid which has an effect on inflammation, angiogenesis and vascular inflammation. In several other flavonoids (e.g. kaempferol, astragalin, alpinetin, baicalein, indirubin), anti-inflammatory mechanism was proven by using mice mastitis model. The aim of the current study was pilot analysis of quercetin tolerability and its impact on somatic cells count (SCC) after multiple...

article

The concomitant use of lapatinib and paracetamol - the risk of interaction

Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, more

Investigational New Drugs > 2018 > 36 > 5 > 819-827

Summary Lapatinib is a tyrosine kinase inhibitor used for the treatment of breast cancer. Paracetamol is an analgesic commonly applied to patients with mild or moderate pain and fever. Cancer patients are polymedicated, which involves high risk of drug interactions during therapy. The aim of the study was to assess the interaction between lapatinib and paracetamol in rats. The rats were divided into...

article

Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys

Tomasz Grabowski, Urszula Pasławska, Błażej Poźniak, Marcin Świtała

Research in Veterinary Science > 2017 > 112 > C > 167-171

Linking haemodynamic (HD) and pharmacokinetic (PK) parameters provides much insight into interrelations between circulatory system and drug disposition. This effect is particularly pronounced in rapidly growing animals. Heart rate (HR), cardiac output (CO) and stroke volume (SV) are tightly linked with the animal's age and correlate with the increasing body weight (BW). The aim of this study was to...

article

Pharmacokinetic drug-drug interaction between erlotinib and paracetamol: A potential risk for clinical practice

Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Tomasz Grabowski, more

European Journal of Pharmaceutical Sciences > 2017 > 102 > C > 55-62

Erlotinib is a tyrosine kinase inhibitor available for the treatment of non-small cell lung cancer. Paracetamol is an analgesic agent, commonly used in cancer patients. Because these drugs are often co-administered, there is an increasing issue of interaction between them.The aim of the study was to investigate the effect of paracetamol on the pharmacokinetic parameters of erlotinib, as well as the...

article

Magnesium cinnamate complex, [Mg(cinn)2(H2O)2]n; structural, spectroscopic, thermal, biological and pharmacokinetical characteristics

Mariola Puszyńska-Tuszkanow, Wiktor Zierkiewicz, Tomasz Grabowski, Marek Daszkiewicz, more

Journal of Molecular Structure > 2017 > 1134 > C > 199-207

The composition and structure of the magnesium complex with cinnamic acid, [Mg(cinn)₂(H₂O)₂]_n (1), were determined using single crystal X-ray diffraction data, IR, NMR spectroscopies, thermal and mass spectrometry analysis. Magnesium cinnamate complex, like the isostructural cobalt(II) species reported in the literature, appears to belong to the group of coordination polymers forming layered solids...

article

The using of a piglets as a model for evaluating the dipyrone hematological effects

Artur Burmańczuk, Andrzej Milczak, Tomasz Grabowski, Monika Osypiuk, more

BMC Veterinary Research > 2016 > 12 > 1 > 1-7

Background Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retain the activity of the parent drug. Its metabolites have analgesic, antipyretic and anti-inflammatory effects. Results The subjects were eight healthy male Large White post-suckling...

article

Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits

Agnieszka Karbownik, Agnieszka Bienert, Włodzimierz Płotek, Tomasz Grabowski, more

European Journal of Drug Metabolism and Pharmacokinetics > 2017 > 42 > 3 > 489-498

Background and Objectives Paracetamol is one of the most common analgesics and antipyretics applied in health care. The aim of the study was to investigate the influence of the time-of-day administration on the paracetamol pharmacokinetics and its penetration into aqueous humour (AH). Methods Rabbits were divided into three groups: I—receiving paracetamol at 08.00 h, II—receiving paracetamol at...

article

Sacrum i profanum na tle krótkiej działalności Muzeum Diecezjalnego w Łomży

Tomasz Grabowski

Archiwa, Biblioteki i Muzea Kościelne > 2016 > 105 > 45-51

Diocesan Museum has been in Łomża since 2012. The first attempt to build it was made in 1925. The plan was to establish the museum as one building but the Diocese did not have enough money. Therefore, Museum had its place in Perish house. Then in 1981 Seminary and Pensioner Priests house was built. Diocesan Museum was to built next to the Priest House but unfortunately there was still no money....

article

Pharmacokinetics of oxytetracycline in broiler chickens following different routes of administration

Hubert Ziółkowski, Tomasz Grabowski, Agnieszka Jasiecka, Monika Zuśka-Prot, more

The Veterinary Journal > 2016 > 208 > C > 96-98

The aim of this study was to determine the pharmacokinetics of oxytetracycline (OTC) in broiler chickens following intravenous (IV), intramuscular (IM), subcutaneous (SC) and oral (PO) administrations at a dose of 15 mg/kg bodyweight. Plasma concentrations of OTC were determined using liquid chromatography–tandem mass spectrometry and non-compartmental pharmacokinetic analysis was then conducted.The...

article

Pharmacokinetic Studies of Oxathio-Heterocycle Fused Chalcones

Krystyna Okoniewska, Marek T. Konieczny, Krzysztof Lemke, Tomasz Grabowski

European Journal of Drug Metabolism and Pharmacokinetics > 2017 > 42 > 1 > 49-58

Background and Objectives Chalcone constitutes one of the most used molecular frameworks in medicinal chemistry and its derivatives exhibit a broad spectrum of biological activities. Low absolute bioavailability, poor distribution, intensive metabolism and elimination of chalcones are the main problems in designing new drugs based on their structure. One of the fundamental steps in evaluation of drug...

article

Classification model of amino acid sequences prone to aggregation of therapeutic proteins

Monika Marczak, Krystyna Okoniewska, Tomasz Grabowski

In Silico Pharmacology > 2016 > 4 > 1 > 1-10

Background Total body clearance of biological drugs is for the most part dependent on the receptor mechanisms (receptor mediated clearance) and the concentration of antibodies aimed at administered drug – anti-drug-antibodies (ADA). One of the significant factors that induces the increase of ADA level after drug administration could be the aggregates present in the finished product or formed in the...

article

Correlation of elimination fraction area under the curve with total body clearance

Tomasz Grabowski, Anna Raczyńska-Pawelec, Marcin Starościak, Jerzy Jan Jaroszewski

European Journal of Drug Metabolism and Pharmacokinetics > 2016 > 41 > 1 > 9-18

This study attempted to determine the area under the curve ( $${\text{AUC}}_{{t_{\text{el}} - t_{\text{last}} }}$$ AUC t el - t last ), which corresponds to the sum of all elimination processes correlated with the total clearance value. The study attempted to determine the $${\text{AUC}}_{{t_{\text{el}} - t_{\text{last}} }}$$ AUC t el - t last based on the coordinates...

article

Metody walki informacyjnej w mediach elektronicznych na przykładzie konfliktu rosyjsko‑ukraińskiego (2014‑2016)

Tomasz Grabowski

Horyzonty Polityki > 2016 > 7 > 20 > 27-53

CEL NAUKOWY: Celem artykułu jest ukazanie współczesnych form walki informacyjnej. PROBLEM I METODY BADAWCZE: Główny problem badawczy dotyczy odpowiedzi na pytanie o rolę zmagań w sferze informacyjnej we współczesnych konfliktach politycznych. Przyjęto hipotezę, iż rola ta wzrasta i skuteczne przeprowadzenie tego typu operacji jest niezbędne do odniesienia pełnego zwycięstwa. W pracy badawczej zastosowano...

article

Erratum to: Quantification of floating ephippia in lakes: a step to a better understanding of high dispersal propensity of freshwater plankters

Mirosław Ślusarczyk, Tomasz Grabowski, Barbara Pietrzak

Hydrobiologia > 2017 > 798 > 1 > 73-73

The online version of the original article can be found under doi: 10.1007/s10750-015-2437-4 .

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INFONA - science communication portal

Search results for: Tomasz Grabowski

Północnokaukascy bojownicy w szeregach Państwa Islamskiego. Profil psychologiczno-społeczny oraz mechanizmy rekrutacji

PHARMACOKINETIC INTERACTION AFTER ORAL COADMINISTRATION OF CLARITHROMYCIN AND THE TYROSINE KINASE INHIBITOR LAPATINIB IN RATS

Fluctuations in Pharmacokinetics Profiles of Monoclonal Antibodies

Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration

The Influence of Diabetes Mellitus on Glucuronidation and Sulphation of Paracetamol in Patients with Febrile Neutropenia

Animal Pharmacokinetic/Pharmacodynamic Studies (APPS) Reporting Guidelines

Quercetin decrease somatic cells count in mastitis of dairy cows

The concomitant use of lapatinib and paracetamol - the risk of interaction

Models describing metronidazole pharmacokinetics in relation to hemodynamics in turkeys

Pharmacokinetic drug-drug interaction between erlotinib and paracetamol: A potential risk for clinical practice

Magnesium cinnamate complex, [Mg(cinn)2(H2O)2]n; structural, spectroscopic, thermal, biological and pharmacokinetical characteristics

The using of a piglets as a model for evaluating the dipyrone hematological effects

Influence of the Time of Intravenous Administration of Paracetamol on its Pharmacokinetics and Ocular Disposition in Rabbits

Sacrum i profanum na tle krótkiej działalności Muzeum Diecezjalnego w Łomży

Pharmacokinetics of oxytetracycline in broiler chickens following different routes of administration

Pharmacokinetic Studies of Oxathio-Heterocycle Fused Chalcones

Classification model of amino acid sequences prone to aggregation of therapeutic proteins

Correlation of elimination fraction area under the curve with total body clearance

Metody walki informacyjnej w mediach elektronicznych na przykładzie konfliktu rosyjsko‑ukraińskiego (2014‑2016)

Erratum to: Quantification of floating ephippia in lakes: a step to a better understanding of high dispersal propensity of freshwater plankters

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