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The aim of this work was to develop a method of characterization and determination of ten quinolones by liquid chromatography (LC) coupled to pneumatically assisted electrospray ionization (ESI) mass spectrometry (MS). For this purpose, the operational parameters of LC-ESI-MS were optimized in order to obtain suitable separations and high sensitivity of the greatest number of quinolones. In the established...
Dissociation constant values of the acid components of the standard NIST scale buffer solutions and of acetate buffer in several hydroorganic mixtures (acetonitrile-water, tetrahydrofuran-water and methanol-water) were first subjected to factor analysis in order to obtain the number of factors that affect the variation of the whole data sets, and then to target factor analysis to identify these factors...
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